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However, the distribution and subunit composition of\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n s in the\n AD<\/jats:styled-content>\n brain are not well understood. This is the first comprehensive study to show brain region\u2010 and cell layer\u2010specific alterations in the expression of the\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n subunits \u03b11\u20103, \u03b15, \u03b21\u20103 and \u03b32 in the human\n AD<\/jats:styled-content>\n hippocampus, entorhinal cortex and superior temporal gyrus. In late\u2010stage\n AD<\/jats:styled-content>\n tissue samples using immunohistochemistry we found significant alteration of all investigated\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n s subunits except for \u03b13 and \u03b21 that were well preserved. The most prominent changes include an increase in\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n \u03b11 expression associated with\n AD<\/jats:styled-content>\n in all layers of the\n CA<\/jats:styled-content>\n 3 region, in the stratum (str.) granulare and hilus of the dentate gyrus. We found a significant increase in\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n \u03b12 expression in the str. oriens of the\n CA<\/jats:styled-content>\n 1\u20103, str. radiatum of the\n CA<\/jats:styled-content>\n 2,3 and decrease in the str. pyramidale of the\n CA<\/jats:styled-content>\n 1 region in\n AD<\/jats:styled-content>\n cases. In\n AD<\/jats:styled-content>\n there was a significant increase in\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n \u03b15 subunit expression in str. pyramidale, str. oriens of the\n CA<\/jats:styled-content>\n 1 region and decrease in the superior temporal gyrus. We also found a significant decrease in the\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n \u03b23 subunit immunoreactivity in the str. oriens of the\n CA<\/jats:styled-content>\n 2, str. granulare and str. moleculare of the dentate gyrus. In conclusion, these findings indicate that the expression of the\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n subunits shows brain region\u2010 and layer\u2010specific alterations in\n AD<\/jats:styled-content>\n , and these changes could significantly influence and alter\n \n GABA\n A<\/jats:sub>\n R\n <\/jats:styled-content>\n function in the disease.\n <\/jats:p>\n <\/jats:sec>\n \n \n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n \n Cover Image<\/jats:bold>\n for this issue: doi:\n 10.1111\/jnc.14179<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jnc.14325","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T05:53:00Z","timestamp":1519710780000},"page":"374-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["\n GABA\n A<\/sub>\n <\/scp>\n receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus"],"prefix":"10.1111","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-4956","authenticated-orcid":false,"given":"Andrea","family":"Kwakowsky","sequence":"first","affiliation":[{"name":"Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Calvo\u2010Flores Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Pandya","sequence":"additional","affiliation":[{"name":"Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton","family":"Turner","sequence":"additional","affiliation":[{"name":"Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"},{"name":"Department of Anatomical Pathology LabPlus Auckland City Hospital Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Waldvogel","sequence":"additional","affiliation":[{"name":"Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Faull","sequence":"additional","affiliation":[{"name":"Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Alzheimer's Disease International(2015)World Alzheimer report 2015: the global impact of dementia.https:\/\/www.alz.co.uk\/research\/world-report-2015."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025063811290"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.09.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0031-6997(24)01363-2","article-title":"International Union of Pharmacology. 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