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Lipidomic specialisation has previously been demonstrated in the neurologically normal human <jats:styled-content style=\"fixed-case\">SVZ<\/jats:styled-content>, with enrichment of functionally important lipid classes in each lamina. The <jats:styled-content style=\"fixed-case\">SVZ<\/jats:styled-content> is also responsive to neurodegenerative disorders, where thickening of the niche and enhanced proliferation of resident cells were observed in Huntington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) brains. In this study, we hypothesised lipidomic changes in the <jats:styled-content style=\"fixed-case\">HD SVZ<\/jats:styled-content>. Using matrix\u2010assisted laser desorption\/ionisation (<jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>) imaging mass spectrometry, this analysis shows differences in the lipidomic architecture in the post\u2010mortem Vonsattel grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> cases. Relative to matched, neurologically normal specimens (<jats:italic>N<\/jats:italic>\u00a0=\u00a04), the lipidomic signature of the <jats:styled-content style=\"fixed-case\">HD SVZ<\/jats:styled-content> (<jats:italic>N<\/jats:italic>\u00a0=\u00a04) was characterized by loss of sulfatides and triglycerides in the myelin layer, with an ectopic and focal accumulation of sphingomyelins and ceramide\u20101\u2010phosphate observed in this lamina. A striking loss of lipidomic patterning was also observed in the ependymal layer, where the local abundance of phosphatidylinositols was significantly reduced in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>. This comprehensive spatially resolved lipidomic analysis of the human <jats:styled-content style=\"fixed-case\">HD SVZ<\/jats:styled-content> identifies alterations in lipid architecture that may shed light on the mechanisms of <jats:styled-content style=\"fixed-case\">SVZ<\/jats:styled-content> responses to neurodegeneration in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Open Practices<\/jats:title><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jnc14468-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p><jats:p>This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/cos.io\/our-services\/open-science-badges\/\">https:\/\/cos.io\/our-services\/open-science-badges\/<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14468-fig-0006-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14468","type":"journal-article","created":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T08:09:15Z","timestamp":1527408555000},"page":"613-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Subventricular zone lipidomic architecture loss in Huntington's disease"],"prefix":"10.1111","volume":"146","author":[{"given":"Mandana","family":"Hunter","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology University of Auckland Auckland New Zealand"},{"name":"Centre for Brain Research University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Demarais","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L. 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