{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:23:38Z","timestamp":1790375018978,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["400133\/2014\u20108"],"award-info":[{"award-number":["400133\/2014\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ\u201000294\u201015"],"award-info":[{"award-number":["APQ\u201000294\u201015"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Huntington's Disease (HD) is an autosomal\u2010dominant neurodegenerative disorder, characterized by involuntary body movements, cognitive impairment, and psychiatric disorder. The metabotropic glutamate receptor 5 (mGluR5) plays an important role in HD and we have recently demonstrated that mGluR5\u2010positive allosteric modulators (PAMs) can ameliorate pathology and the phenotypic signs of a mouse model of HD. In this study, we investigated the molecular mechanisms involved in mGluR5 PAMs effect on memory. Our results demonstrate that subchronic treatment with the mGluR5 PAM VU0409551 was effective in reversing the memory deficits exhibited by BACHD mice, a mouse model for HD. Moreover, VU0409551 treatment stabilized mGluR5 at the cellular plasma membrane of BACHD mice, increasing the expression of several genes important for synaptic plasticity, including c\u2010Fos, brain\u2010derived neurotrophic factor, Arc\/Arg3.1, syntaxin 1A, and post\u2010synaptic density\u201095. In addition, VU0409551 treatment also increased dendritic spine density and maturation and augmented the number of pre\u2010synaptic sites. In conclusion, our results demonstrate that VU0409551 triggered the activation of cell signaling pathways important for synaptic plasticity, enhancing the level of dendritic spine maturation and rescuing BACHD memory impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Open Practices<\/jats:title>\n                    <jats:p>\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jnc14555-gra-0001.png\" xlink:title=\"image\"\/>\n                    <\/jats:p>\n                    <jats:p>Open Science: This manuscript was awarded with the Open Materials Badge.<\/jats:p>\n                    <jats:p>\n                      For more information see:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/cos.io\/our-services\/open-science-badges\/\">https:\/\/cos.io\/our-services\/open-science-badges\/<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14555-fig-0007-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jnc.14555","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T05:24:25Z","timestamp":1532064265000},"page":"222-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The mGluR5 positive allosteric modulator VU0409551 improves synaptic plasticity and memory of a mouse model of Huntington's disease"],"prefix":"10.1111","volume":"147","author":[{"given":"Juliana G.","family":"Doria","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences (ICB) Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences (ICB) Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia R.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences (ICB) Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella G.","family":"Olmo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences (ICB) Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toniana G.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences (ICB) Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Alves\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences (ICB) Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita H.","family":"Ferreira\u2010Vieira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences (ICB) Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica T.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences (ICB) Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudymara Q. 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