{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:08:35Z","timestamp":1768972115955,"version":"3.49.0"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81671500"],"award-info":[{"award-number":["No. 81671500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Hypoxic\u2010ischemic brain damage (HIBD) which is a common cause of acute mortality and neurological dysfunction in neonates still lacks effective therapeutic methods. Long non\u2010coding RNAs (lncRNAs) were demonstrated to play a crucial role in many diseases. To give a foundation for subsequent functional studies of lncRNAs in HIBD, we investigated the profiling of lncRNAs and messenger RNAs (mRNAs) using neonatal HIBD rat model. Six neonatal rats were divided into sham\u2010operated group (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) and HIBD group (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) randomly. Deep RNA sequencing was implemented to find out the meaningful lncRNAs and mRNAs. Quantitative real\u2010time PCR was used to validate expressions of lncRNAs and mRNAs. The Gene Ontology (GO) and kyoto encyclopedia of genes a genomes (KEGG) database were used to predict functions of lncRNAs. A total of 328 differentially expressed lncRNAs (177 down\u2010regulated vs 151 up\u2010regulated) and 7157 differentially expressed mRNAs (2552 down\u2010regulated vs 4605 up\u2010regulated) were identified. The Quantitative real\u2010time PCR results showed significant differential expressions of five lncRNAs and five mRNAs which were consistent with the RNA\u2010Seq data. Gene ontology and KEGG analysis showed these lncRNAs and their expression\u2010correlated mRNAs were closely related to the Janus tyrosine kinase\u2010signal transducer and activator of transcription (JAK\u2010STAT) signaling pathway, NF\u2010kappa B signaling pathway, Toll\u2010like receptor signaling pathway, calcium signaling pathway, Notch signaling pathway, mitogen activated protein kinase signaling pathway, neuroactive ligand\u2010receptor interaction pathway and more. The results of our study identified the characterization and expression profiles of lncRNAs in neonatal HIBD and may be a basis for further therapeutic research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Open Science Badges<\/jats:title><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jnc14689-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jnc14689-gra-0002.png\" xlink:title=\"image\"\/><\/jats:p><jats:p>This article has received a badge for *<jats:bold>Open Materials<\/jats:bold>* and *<jats:bold>Open Data<\/jats:bold>* because it provided all relevant information to reproduce the study in the manuscript and because it made the data publicly available. The data can be accessed at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/osf.io\/yf3da\/\">https:\/\/osf.io\/yf3da\/<\/jats:ext-link>. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/cos.io\/our-services\/open-science-badges\/\">https:\/\/cos.io\/our-services\/open-science-badges\/<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14689-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14689","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T06:51:38Z","timestamp":1551163898000},"page":"346-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of long non\u2010coding RNA expression profiles in neonatal rats with hypoxic\u2010ischemic brain damage"],"prefix":"10.1111","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6107-5327","authenticated-orcid":false,"given":"Han","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Newborn Infants Children's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants Children's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants Children's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants Children's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants Children's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants Children's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants Children's Hospital of Nanjing Medical University Nanjing Jiangsu 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