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Mice were subjected to rotarod tests of motor coordination, and open field and cylinder tests for spontaneous locomotor activity and postural axial support. To measure <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release in dorsal striatum and the shell of Nucleus Accumbens (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c), we used <jats:italic>ex\u00a0vivo<\/jats:italic> fast\u2010scan cyclic voltammetry in 6\u2010 to 24\u2010week\u2010old mice. To determine decline of <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> transporter function, we used 18<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>2I positron emission tomography. We show here that fast\u2010scan cyclic voltammetry is a sensitive tool to detect evoked <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release dysfunction in MitoPark mice and that electrically evoked <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release is affected earlier in nigrostriatal than mesolimbic <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> systems. <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> reuptake was also affected more slowly in <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c shell. Positron emission tomography data showed <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> uptake to be barely above detection levels in 16\u2010 and 20\u2010week\u2010old MitoPark mice. Rotarod performance was not impaired until mice were 16\u00a0weeks old, when evoked <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release in striatum had decreased to \u2248\u00a040% of wild\u2010type levels. In contrast, impairment of open field locomotion and rearing began at 10\u00a0weeks, in parallel with the initial modest decline of evoked <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release. We conclude that forced behaviors, such as motivation not to fall, can be partially maintained even when <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release is severely compromised, whereas spontaneous behaviors are much more sensitive to impaired <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release, and that presumed secondary non\u2010dopaminergic system alterations do not markedly counteract or aggravate effects of severe impairment of <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> release.<\/jats:p><\/jats:sec><jats:sec><jats:title>Open Science Badges<\/jats:title><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jnc14702-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p><jats:p>This article has received a badge for *<jats:bold>Open Materials<\/jats:bold>* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/cos.io\/our-services\/open-science-badges\/\">https:\/\/cos.io\/our-services\/open-science-badges\/<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14702-fig-0010-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14702","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T15:32:27Z","timestamp":1554132747000},"page":"56-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors"],"prefix":"10.1111","volume":"150","author":[{"given":"Yuan\u2010Hao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery Tri\u2010Service General Hospital Natl Defense Medical Center Taipei Taiwan R.O.C"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Hsun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Graduate Institute of Rehabilitation Science Chang Gung University Taoyuan Taiwan"},{"name":"Neuroscience Research Center Chang Gung Memorial Hospital Linkou Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung\u2010Tai","family":"Kuo","sequence":"additional","affiliation":[{"name":"Graduate Institute of Computer and Communication Engineering Natl Taipei University of Technology Taipei Taiwan 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