{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:25:00Z","timestamp":1791469500596,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["KYQD160601"],"award-info":[{"award-number":["KYQD160601"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Endoplasmic reticulum (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) stress has been highlighted as one of the factors involved in axon\/dendrite degeneration, which is an early event in Alzheimer's, Parkinson's diseases as well as in acute disorders such as ischemia and axotomy\u2010induced retinal ganglion cell degeneration. These lines of evidence suggest critical roles of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress at the early stage of neurodegeneration, but the relevant mechanism is rarely exploited. In this study, we report that treatment with sublethal level of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stressors, tunicamycin or brefeldin A, in primary rat neuronal cultures, significantly reduced dendrite arbor. Under the same treatment, either stressor reduced store\u2010operated calcium entry (<jats:styled-content style=\"fixed-case\">SOCE<\/jats:styled-content>) and cytosolic calcium, [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, which were associated with autophagic degradation of stromal interaction molecule 2 (<jats:styled-content style=\"fixed-case\">STIM<\/jats:styled-content>2). Knockdown of <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>7 or activating transcription factor 4 completely reversed the reduction of <jats:styled-content style=\"fixed-case\">STIM<\/jats:styled-content>2 and significantly reversed the inhibition of <jats:styled-content style=\"fixed-case\">SOCE<\/jats:styled-content> under <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress. Overexpression of <jats:styled-content style=\"fixed-case\">STIM<\/jats:styled-content>2 in neurons significantly prevented the <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress\u2010induced disruption of dendrite arbor. Altogether, our data reveal an unprecedented mechanism by which <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress induces dendrite degeneration, that is, <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress induces autophagic degradation of <jats:styled-content style=\"fixed-case\">STIM<\/jats:styled-content>2, leading to ensued <jats:styled-content style=\"fixed-case\">SOCE<\/jats:styled-content> inhibition and reduced [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, resulting in trimming effect on dendrites.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14712-fig-0009-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14712","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T03:15:36Z","timestamp":1556680536000},"page":"351-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress"],"prefix":"10.1111","volume":"151","author":[{"given":"Jing","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Optometry and Ophthalmology and the Eye Hospital Wenzhou Medical University Wenzhou Zhejiang P.R. China"},{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science Wenzhou Zhejiang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Song","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and the Eye Hospital Wenzhou Medical University Wenzhou Zhejiang P.R. China"},{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science Wenzhou Zhejiang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-2369","authenticated-orcid":false,"given":"Shengzhou","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and the Eye Hospital Wenzhou Medical University Wenzhou Zhejiang P.R. China"},{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science Wenzhou Zhejiang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn312"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt563"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200507002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101902"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.039"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10048"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5968-10.2011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3266"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00302.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.10.025"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.08.025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.026"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.12.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0750436.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3486"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.21.7405-7416.2002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23413"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2016.01.007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02141.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.964702"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.4.793"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-03-01190.2000"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00234-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn770"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/35086067"},{"key":"e_1_2_9_31_1","article-title":"DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders","author":"Meng X.","year":"2016","journal-title":"J. Neurochem."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.8.4702"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-14-05329.2000"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.992302"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21191"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608942200"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103160"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04671.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2199"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.028"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61332"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105681"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.019"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81010-7"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600455"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.059"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.664"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400541101"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.07.005"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06037.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26373"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00066-0"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00611-0"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.10.017"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04147"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1034-15.2015"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00485.2004"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.14712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.14712","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.14712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T03:58:33Z","timestamp":1694231913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.14712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/jnc.14712"],"URL":"https:\/\/doi.org\/10.1111\/jnc.14712","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"assertion":[{"value":"2018-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}