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Adenosine A<jats:sub>1<\/jats:sub> receptor agonists promote hibernation in different mammalian species, and the understanding of the mechanism inducing hibernation will inform clinical strategies to manipulate metabolic demand that are fundamental to conditions such as obesity, metabolic syndrome, and therapeutic hypothermia. Adenosine A<jats:sub>1<\/jats:sub> receptor agonist\u2010induced hibernation in Arctic ground squirrels is regulated by an endogenous circannual (seasonal) rhythm. This study aims to identify the neuronal mechanism underlying the seasonal difference in response to the adenosine A<jats:sub>1<\/jats:sub> receptor agonist. Arctic ground squirrels were implanted with body temperature transmitters and housed at constant ambient temperature (2\u00b0C) and light cycle (4L:20D). We administered CHA (N<jats:sup>6<\/jats:sup>\u2010cyclohexyladenosine), an adenosine A<jats:sub>1<\/jats:sub> receptor agonist in euthermic\u2010summer phenotype and euthermic\u2010winter phenotype and used cFos and phenotypic immunoreactivity to identify cell groups affected by season and treatment. We observed lower core and subcutaneous temperature in winter animals and CHA produced a hibernation\u2010like response in winter, but not in summer. cFos\u2010ir was greater in the median preoptic nucleus and the raphe pallidus in summer after CHA. CHA administration also resulted in enhanced cFos\u2010ir in the nucleus tractus solitarius and decreased cFos\u2010ir in the tuberomammillary nucleus in both seasons. In winter, cFos\u2010ir was greater in the supraoptic nucleus and lower in the raphe pallidus than in summer. The seasonal decrease in the thermogenic response to CHA and the seasonal increase in vasoconstriction, assessed by subcutaneous temperature, reflect the endogenous seasonal modulation of the thermoregulatory systems necessary for CHA\u2010induced hibernation.<\/jats:p><jats:p>Cover Image for this issue: doi: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1111\/jnc.14528\">10.1111\/jnc.14528<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14814-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14814","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T09:03:20Z","timestamp":1562317400000},"page":"316-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N<sup>6<\/sup>\u2010cyclohexyladenosine\u2010induced hibernation in the Arctic ground squirrel (<i>Urocitellus parryii<\/i>)"],"prefix":"10.1111","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-5893","authenticated-orcid":false,"given":"Carla","family":"Frare","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Alaska Fairbanks Fairbanks Alaska USA"},{"name":"Institute of Arctic Biology University of Alaska Fairbanks Fairbanks Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie E.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Alaska Fairbanks Fairbanks Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey M.","family":"McClure","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Colorado State University Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Drew","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Alaska Fairbanks Fairbanks Alaska USA"},{"name":"Institute of Arctic Biology University of Alaska Fairbanks Fairbanks Alaska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90511.2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12549"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb03463.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004128.pub4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1946.sp004129"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2740905"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90723-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015909789152182"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21507"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.1.R255"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00039.2010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3596-12.2013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199709080-00002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/23.4.9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21212"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.232314"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06848.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-2109-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3144-11.2011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"9224","DOI":"10.1523\/JNEUROSCI.20-24-09224.2000","article-title":"Association of cocaine\u2010 and amphetamine\u2010regulated transcript\u2010immunoreactive elements with thyrotropin\u2010releasing hormone\u2010synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic\u2010pituitary\u2010thyroid axis during fasting","volume":"20","author":"Fekete C.","year":"2000","journal-title":"J. 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