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(2019) in the current issue of the <jats:italic>Journal of Neurochemistry<\/jats:italic>, in which the authors describe a microcephalic boy carrying the novel heterozygous <jats:italic>de novo<\/jats:italic> missense mutation c.560A&gt;\u00a0G; p.Asp187Gly in <jats:italic>Cdh1\/Fzr1<\/jats:italic> encoding the APC\/C E3\u2010ubiquitin ligase cofactor CDH1. A functional characterization of mutant APC\/C<jats:sup>CDH1<\/jats:sup> confirms an aberrant division of neural progenitor cells, a condition known to determine the mouse brain cortex size. These data suggest that APC\/C<jats:sup>CDH1<\/jats:sup> may contribute to the regulation of the human brain size.<\/jats:p><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14835-fig-0002-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p>","DOI":"10.1111\/jnc.14835","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T11:57:14Z","timestamp":1566561434000},"page":"8-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Does APC\/C<sup>CDH1<\/sup> control the human brain size?"],"prefix":"10.1111","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-9807","authenticated-orcid":false,"given":"Maike F.","family":"Dohrn","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical Faculty RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3949-6862","authenticated-orcid":false,"given":"Juan P.","family":"Bola\u00f1os","sequence":"additional","affiliation":[{"name":"Institute of Functional Biology and Genomics CSIC, University of Salamanca Salamanca Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES) Institute of Biomedical Research of Salamanca Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1143-05.2005"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws019"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616024114"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13486"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3879"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-8-S1-S4"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.010"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1742"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1881"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.10.179"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14828"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.09.011"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.14835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.14835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.14835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:52:46Z","timestamp":1693828366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.14835"}},"subtitle":["An Editorial Highlight for \u2018A novel human <i>Cdh1<\/i> mutation impairs anaphase\u2010promoting complex\/cyclosome (APC\/C) activity resulting in microcephaly, psychomotor retardation, and epilepsy\u2019 on page 103"],"short-title":[],"issued":{"date-parts":[[2019,8,23]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/jnc.14835"],"URL":"https:\/\/doi.org\/10.1111\/jnc.14835","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"type":"print","value":"0022-3042"},{"type":"electronic","value":"1471-4159"}],"subject":[],"published":{"date-parts":[[2019,8,23]]},"assertion":[{"value":"2019-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}