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Our previous study demonstrated that GSK3\u03b2 activity is highly induced during cocaine memory reactivation, and that reconsolidation of cocaine reward memory is attenuated by inhibition of GSK3\u03b2. NMDA receptors and protein phosphatase 1 (PP1) are activators of GSK3\u03b2. Thus, this study investigated the roles of NMDA receptor subtypes and PP1in the reconsolidation of cocaine contextual reward memory. Cocaine contextual memories were established and evaluated using cocaine conditioned place preference methods. The regulation of GSK3\u03b2 activity in specific brain areas was assessed by measuring its phosphorylation state using immunoblot assays. Mice underwent cocaine place conditioning for 8\u00a0days and were tested for place preference on day 9. Twenty\u2010four hours later, mice were briefly confined to the compartment previous paired with cocaine to reactivate cocaine\u2010associated memories. Administration of the GluN2A\u2010 and GluN2B\u2010NMDA receptor antagonists, NVP\u2010AAM077 and ifenprodil, respectively, immediately following recall abrogated an established cocaine place preference, while preventing the activation of GSK3\u03b2 in the amygdala, nucleus accumbens, and hippocampus during cocaine memory reactivation. PP1 inhibition with okadaic acid also blocked the activation of GSK3\u03b2 and attenuated a previously established cocaine place preference. These findings suggest that the dephosphorylation of GSK3\u03b2 that occurred upon activation of cocaine\u2010associated reward memories may be initiated by the activation of PP1 during the induction of NMDA receptor\u2010dependent reconsolidation of cocaine mnemonic traces. Moreover, the importance of NMDA receptors and PP1 in reconsolidation of cocaine memory makes them potential therapeutic targets in treatment of cocaine use disorder and prevention of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14842-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14842","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T10:29:48Z","timestamp":1564482588000},"page":"91-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Activation of GSK3\u03b2 induced by recall of cocaine reward memories is dependent on GluN2A\/B NMDA receptor 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