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Although most studies are focused on chemical synapses (glutamate, \u03b3\u2010aminobutyric acid, and other neurotransmitters), clearly both types of synapses interact and cooperate to allow the coordination of several cell functions within the nervous system. The pineal gland has limited independent axonal innervation and not every cell has access to nerve terminals. Thus, additional communication systems, such as gap junctions, have been postulated to coordinate metabolism and signaling. Using acutely isolated glands and dissociated cells, we found that gap junctions spread glycogenolytic signals from cells containing adrenoreceptors to the entire gland lacking these receptors. Our data using glycogen and lactate quantification, electrical stimulation, and high\u2010performance liquid chromatography with electrochemical detection, demonstrate that gap junctional communication between cells of the rat pineal gland allows cell\u2010to\u2010cell propagation of norepinephrine\u2010induced signal that promotes glycogenolysis throughout the entire gland. Thus, the interplay of both synapses is essential for coordinating glycogen metabolism and lactate production in the pineal gland.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14846-fig-0006-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14846","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T14:38:59Z","timestamp":1565015939000},"page":"558-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gap junctions coordinate the propagation of <i>glycogenolysis<\/i> induced by norepinephrine in the pineal gland"],"prefix":"10.1111","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-4720","authenticated-orcid":false,"given":"Eliseo A.","family":"Eugenin","sequence":"first","affiliation":[{"name":"University of Texas Medical Branch Galveston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Valdebenito","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch Galveston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Gorska","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch Galveston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustin D.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias Centro interdisciplinario de Neurociencias, Universidad de Valpara\u00edso Valpara\u00edso Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Bitran","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"S\u00e1ez","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias Centro interdisciplinario de Neurociencias, Universidad de Valpara\u00edso Valpara\u00edso Chile"},{"name":"Departamento de Fisiologia Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"360","article-title":"A study of the factors affecting the aluminum oxide\u2010trihydroxyindole procedure for the analysis of catecholamines","volume":"138","author":"Anton A. 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