{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:06:51Z","timestamp":1775909211590,"version":"3.50.1"},"reference-count":114,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Retinal hypoxia triggers abnormal vessel growth and microvascular hyper\u2010permeability in ischemic retinopathies. Whereas vascular endothelial growth factor A (VEGF\u2010A) inhibitors significantly hinder disease progression, their benefits to retinal neurons remain poorly understood. Similar to humans, oxygen\u2010induced retinopathy (OIR) mice exhibit severe retinal microvascular malformations and profound neuronal dysfunction. OIR mice are thus a phenocopy of human retinopathy of prematurity, and a proxy for investigating advanced stages of proliferative diabetic retinopathy. Hence, the OIR model offers an excellent platform for assessing morpho\u2010functional responses of the ischemic retina to anti\u2010angiogenic therapies. Using this model, we investigated the retinal responses to VEGF\u2010Trap (Aflibercept), an anti\u2010angiogenic agent recognizing ligands of VEGF receptors 1 and 2 that possesses regulatory approval for the treatment of neovascular age\u2010related macular degeneration, macular edema secondary to retinal vein occlusion and diabetic macular edema. Our results indicate that Aflibercept not only reduces the severity of retinal microvascular aberrations but also significantly improves neuroretinal function. Aflibercept administration significantly enhanced light\u2010responsiveness, as revealed by electroretinographic examinations, and led to increased numbers of dopaminergic amacrine cells. Additionally, retinal transcriptional profiling revealed the concerted regulation of both angiogenic and neuronal targets, including transcripts encoding subunits of transmitter receptors relevant to amacrine cell function. Thus, Aflibercept represents a promising therapeutic alternative for the treatment of further progressive ischemic retinal neurovasculopathies beyond the set of disease conditions for which it has regulatory approval.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14875-fig-0009-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p>Cover Image for this issue: doi: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1111\/jnc.14743\">10.1111\/jnc.14743<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14875","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T15:30:16Z","timestamp":1569339016000},"page":"390-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["VEGF\u2010Trap is a potent modulator of vasoregenerative responses and protects dopaminergic amacrine network integrity in degenerative ischemic neovascular retinopathy"],"prefix":"10.1111","volume":"153","author":[{"given":"Jes\u00fas E.","family":"Rojo Arias","sequence":"first","affiliation":[{"name":"Department of Anatomy Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matina","family":"Economopoulou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Ju\u00e1rez L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anica","family":"Kurzbach","sequence":"additional","affiliation":[{"name":"Medizinische Klinik III Universit\u00e4tsklinikum Carl Gustav Carus Technische Universit\u00e4t Dresden Saxony Germany"},{"name":"German Center for Diabetes Research (DZD e.V.) M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan H.","family":"Au Yeung","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Englmaier","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Merdausl","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schaarschmidt","sequence":"additional","affiliation":[{"name":"Department of Anatomy Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Ader","sequence":"additional","affiliation":[{"name":"DFG\u2010Center for Regenerative Therapies Dresden Cluster of Excellence Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Morawietz","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Carl Gustav Carus Division of Vascular Endothelium and Microcirculation Technische Universit\u00e4t Dresden Saxony Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H. 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