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This pathway requires the adenosine A<jats:sub>2A<\/jats:sub> receptor and STEP phosphatases. Activation of the adenosine A<jats:sub>2A<\/jats:sub> receptor leads to an increase in intracellular calcium, activation of STEP by dephosphorylation, inhibition of excitatory ionotropic glutamate receptors by dephosphorylation of phospho\u2010tyrosine residues and subsequent internalization of the ionotropic glutamate receptors. This adenosine A<jats:sub>2A<\/jats:sub> receptor pathway could lead to potential drug targets for neurologic and neuropsychiatric disorders.<\/jats:p><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14901-fig-0002-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p>","DOI":"10.1111\/jnc.14901","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T08:48:14Z","timestamp":1573721294000},"page":"270-272","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adenosine STEPs on synaptic function"],"prefix":"10.1111","volume":"152","author":[{"given":"Robert P.","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Physiology Georgetown University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.10.007"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0887-1"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.229"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01096-5"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.3.1307"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.05.015"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003053"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2010.12.001"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.09.007"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0157-10.2010"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14866"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.15175"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.312"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn989"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3118-5"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408305102"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.368654"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.14901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.14901","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.14901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:47:12Z","timestamp":1694166432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.14901"}},"subtitle":["An Editorial for \u2018The activity of the STriatal\u2010enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A2A receptor on\u2019 page 284."],"short-title":[],"issued":{"date-parts":[[2019,11,14]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/jnc.14901"],"URL":"https:\/\/doi.org\/10.1111\/jnc.14901","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,14]]},"assertion":[{"value":"2019-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}