{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:43Z","timestamp":1772160703862,"version":"3.50.1"},"reference-count":88,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R00 DA040004"],"award-info":[{"award-number":["R00 DA040004"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA007288"],"award-info":[{"award-number":["T32 DA007288"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Cue\u2010induced reinstatement of cocaine seeking after self\u2010administration (SA) and extinction relies on glutamate release in the nucleus accumbens core (NAcore), which activates neuronal nitric oxide synthase interneurons. Nitric oxide (NO) is required for structural plasticity in NAcore medium spiny neurons, as well as cued cocaine seeking. However, NO release in the NAcore during reinstatement has yet to be directly measured. Furthermore, the temporal relationship between glutamate release and the induction of an NO response also remains unknown. Using wireless amperometric recordings in awake behaving rats, we quantified the magnitude and temporal dynamics of novel context\u2010 and cue\u2010induced reinstatement\u2010evoked glutamate and NO release in the NAcore. We found that re\u2010exposure to cocaine\u2010conditioned stimuli following SA and extinction increased extracellular glutamate, leading to release of NO in the NAcore. In contrast, exposing drug\u2010na\u00efve rats to a novel context led to a lower magnitude rise in glutamate in the NAcore relative to cue\u2010induced reinstatement. Interestingly, novel context exposure evoked a higher magnitude NO response relative to cue\u2010induced reinstatement. Despite differences in magnitude, novel context evoked\u2010NO release in the NAcore was also temporally delayed when compared to glutamate. These results demonstrate a dissociation between the magnitude of cocaine cue\u2010 and novel context\u2010evoked glutamate and NO release in the NAcore, yet similarity in the temporal dynamics of their release. Together, these data contribute to a greater understanding of the relationship between glutamate and NO, two neurotransmitters implicated in encoding the valence of distinct contextual stimuli.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14952-fig-0008-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jnc.14952","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T06:07:45Z","timestamp":1578118065000},"page":"599-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Amperometric measurements of cocaine cue and novel context\u2010evoked glutamate and nitric oxide release in the nucleus accumbens core"],"prefix":"10.1111","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-6054","authenticated-orcid":false,"given":"Benjamin M.","family":"Siemsen","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine Medical University of South Carolina Charleston SC USA"},{"name":"Department of Neuroscience Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"McFaddin","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiana","family":"Haigh","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley G.","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Nan Leath","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaylee N.","family":"Hooker","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilly K.","family":"McGonegal","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2330-6999","authenticated-orcid":false,"given":"Michael D.","family":"Scofield","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Medicine Medical University of South Carolina Charleston SC USA"},{"name":"Department of Neuroscience Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-005-0298-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13796.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1069"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1300.023"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-001-0122-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2006.03.026"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(08)01220-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.12.019"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01441.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00891.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3120-y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0010429"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00018-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2003.14.3.207"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-15-j0006.2000"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.04.039"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0529-6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2004.12.017"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr304"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac960093w"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20738"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.03.982"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00262.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1332-18.2018"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.032"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014253618835"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00027"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073634"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0330-16.2017"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.02.011"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07066.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61737-964-2_1"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90870-2"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.03.028"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14290"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050779"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20446"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199808030-00011"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.11.006"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033809"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.46"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443894"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.010"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90174-6"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.07.018"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00079-9"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.10.4205"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2000.01448.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20750"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0537-18.2018"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03531.2003"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb12798.x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1007-05.2005"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011265108"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06416.x"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02916.2002"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13284"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(96)00152-9"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12127"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213476"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05657-9"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2010.08.004"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5745"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04596.x"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300826"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04811.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.05.016"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-013-9878-x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-008-9006-5"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00848-K"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.012484"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.12.022"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908949106"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221295110"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-018-1805-z"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12504"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.03.040"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-011-0224-0"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3846"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2673-16.2016"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00213"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1570-13.2013"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-0997-8"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0925-05.2005"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01167.2011"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.1.162"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1249"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.14952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.14952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.14952","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.14952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T09:57:33Z","timestamp":1693994253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.14952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,3]]},"references-count":88,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/jnc.14952"],"URL":"https:\/\/doi.org\/10.1111\/jnc.14952","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/826677","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,3]]},"assertion":[{"value":"2019-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}