{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:56:15Z","timestamp":1791615375889,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471144"],"award-info":[{"award-number":["81471144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Voltage\u2010gated potassium channels (Kv) are important regulators of neuronal excitability for its role of regulating resting membrane potential and repolarization. Recent studies show that Kv channels participate in neuropathic pain, but the detailed underlying mechanisms are far from being clear. In this study, we used siRNA, miR\u2010137 agomir, and antagomir to regulate the expression of Kv1.2 in spinal cord and dorsal root ganglia (DRG) of na\u00efve and chronic constriction injury (CCI) rats. Kv currents and neuron excitability in DRG neurons were examined by patch\u2010clamp whole\u2010cell recording to verify the change in Kv1.2 function. The results showed that Kv1.2 was down\u2010regulated in DRG and spinal dorsal horn (SDH) by CCI. Knockdown of Kv1.2 by intrathecally injecting <jats:italic>Kcna2<\/jats:italic> siRNA induced significant mechanical and thermal hypersensitivity in na\u00efve rats. Concomitant with the down\u2010regulation of Kv1.2 was an increase in the expression of the miR\u2010137. The targeting and regulating of miR\u2010137 on <jats:italic>Kcna2<\/jats:italic> was verified by dual\u2010luciferase reporter system and intrathecal injecting miR\u2010137 agomir. Furthermore, rescuing the expression of Kv1.2 in CCI rats, achieved through inhibiting miR\u2010137, restored the abnormal Kv currents and excitability in DRG neurons, and alleviated mechanical allodynia and thermal hyperalgesia. These results indicate that the miR\u2010137\u2010mediated Kv1.2 impairment is a crucial etiopathogenesis for the nerve injury\u2010induced neuropathic pain and can be a novel potential therapeutic target for neuropathic pain management.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15117-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15117","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T06:35:12Z","timestamp":1593844512000},"page":"367-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Epigenetic restoration of voltage\u2010gated potassium channel Kv1.2 alleviates nerve injury\u2010induced neuropathic pain"],"prefix":"10.1111","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-4314","authenticated-orcid":false,"given":"Jingjing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Human Anatomy School of Basic Medical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy School of Basic Medical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy School of Basic Medical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy 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