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Individuals with ASD spend less time engaging in social interaction compared to non\u2010affected subjects. Studies employing structural and functional magnetic resonance imaging reported morphological and functional abnormalities in the connectivity of the mesocorticolimbic reward pathway between the nucleus accumbens and the ventral tegmental area (VTA) in response to social stimuli, as well as diminished medial prefrontal cortex in response to visual cues, whereas stronger reward system responses for the non\u2010social realm (e.g., video games) than social rewards (e.g., approval), associated with caudate nucleus responsiveness in ASD children. Defects in the mesocorticolimbic reward pathway have been modulated in transgenic murine models using D2 dopamine receptor heterozygous (D2+\/\u2212) or dopamine transporter knockout mice, which exhibit sociability deficits and repetitive behaviors observed in ASD phenotypes. Notably, the mesocorticolimbic reward pathway is modulated by systemic and central inflammation, such as primed microglia, which occurs during obesity or maternal overnutrition. Therefore, we propose that a positive energy balance during obesity\/maternal overnutrition coordinates a systemic and central inflammatory crosstalk that modulates the dopaminergic neurotransmission in selective brain areas of the mesocorticolimbic reward pathway. Here, we will describe how obesity\/maternal overnutrition may prime microglia, causing abnormalities in dopamine neurotransmission of the mesocorticolimbic reward pathway, postulating a possible immune role in the development of ASD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15141-fig-0004-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jnc.15141","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T11:46:22Z","timestamp":1596973582000},"page":"415-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Potential role of primed microglia during obesity on the mesocorticolimbic circuit in autism spectrum disorder"],"prefix":"10.1111","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-3054","authenticated-orcid":false,"given":"Luis A\u2010","family":"Trujillo Villarreal","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n San Nicolas de los Garza M\u00e9xico"},{"name":"Unidad de Neurometabolismo Centro de Investigaci\u00f3n y Desarrollo en Ciencias de la Salud Universidad Aut\u00f3noma de Nuevo Le\u00f3n San Nicolas de los Garza M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-6781","authenticated-orcid":false,"given":"Marcela","family":"C\u00e1rdenas\u2010Tueme","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Gen\u00e9tica Facultad de Ciencias Biol\u00f3gicas Universidad Aut\u00f3noma de Nuevo Le\u00f3n San Nicolas de los Garza M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-0219","authenticated-orcid":false,"given":"Roger","family":"Maldonado\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n San Nicolas de los Garza M\u00e9xico"},{"name":"Unidad de Neurometabolismo Centro de Investigaci\u00f3n y Desarrollo en Ciencias de la Salud Universidad Aut\u00f3noma de Nuevo Le\u00f3n San Nicolas de los Garza M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-7677","authenticated-orcid":false,"given":"Diana","family":"Res\u00e9ndez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Gen\u00e9tica Facultad de Ciencias Biol\u00f3gicas Universidad Aut\u00f3noma de Nuevo Le\u00f3n San Nicolas de los Garza M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-9489","authenticated-orcid":false,"given":"Alberto","family":"Camacho\u2010Morales","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n San Nicolas de los Garza M\u00e9xico"},{"name":"Unidad de Neurometabolismo Centro de Investigaci\u00f3n y Desarrollo en Ciencias de la Salud Universidad Aut\u00f3noma de Nuevo Le\u00f3n San Nicolas de los Garza M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.639803"},{"key":"e_1_2_11_3_1","first-page":"1","article-title":"Optogenetic insights on the relationship between anxiety\u2010related behaviors and social deficits","volume":"8","author":"Allsop S. 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