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The binding residues between Nn\u2010\u03b1\u2010elapitoxin\u20101 and mammalian TrkA receptor are predicted by in silico analysis. This binding results in a time\u2010dependent internalization of TrkA receptor into the cytoplasm of PC\u201012 cells. The transcriptomic analysis has demonstrated the differential expression of 445 genes; 38 and 32 genes are up\u2010regulated and down\u2010regulated, respectively in the PC\u201012 cells post\u2010treatment with Nn\u2010\u03b1\u2010elapitoxin\u20101. Global proteomic analysis in concurrence with transcriptomic data has also demonstrated that in addition to expression of a large number of common intracellular proteins in the control and Nn\u2010\u03b1\u2010elapitoxin\u20101\u2010treated PC\u201012 cells, the latter cells also showed the expression of uniquely up\u2010regulated and down\u2010regulated intracellular proteins involved in diverse cellular functions. Altogether, the data from transcriptomics, proteomics, and inhibition of downstream signaling pathways by specific inhibitors, and the immunoblot analysis of major regulators of signaling pathways of neuritogenesis unambiguously demonstrate that, similar to mouse 2.5S\u2010nerve growth factor, the activation of mitogen activated protein kinase\/extracellular signal\u2010regulated kinase is the major signaling pathway for neuritogenesis by Nn\u2010\u03b1\u2010elapitoxin\u20101. Nonetheless, fibroblast growth factor signaling and heterotrimeric G\u2010protein signaling pathways were found to be uniquely expressed in Nn\u2010\u03b1\u2010elapitoxin\u20101\u2010treated PC\u201012 cells and not in mouse 2.5S\u2010nerve growth factor \u2010treated cells. The TrkA binding region of Nn\u2010\u03b1\u2010elapitoxin\u20101 may be developed as a peptide\u2010based drug prototype for the treatment of major central neurodegenerative diseases.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15153-fig-0009-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p>Read the Editorial Highlight for this article on page <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" 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