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Dysfunction of mitochondria has been associated with several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, Glaucoma and Amyotrophic Lateral Sclerosis. The focus of this review is on how and why mitochondrial function is linked to the pathology of Parkinson's disease (PD). Many of the PD\u2010linked genetic mutations which have been identified result in dysfunctional mitochondria, through a wide\u2010spread number of mechanisms. In this review, we describe how susceptible neurons are predisposed to be vulnerable to the toxic events that occur during the neurodegenerative process of PD, and how mitochondria are central to these pathways. We also discuss ways in which proteins linked with familial PD control mitochondrial function, both physiologically and pathologically, along with their implications in genome\u2010wide association studies and risk assessment. Finally, we review potential strategies for disease modification through mitochondrial enhancement. Ultimately, agents capable of both improving and\/or restoring mitochondrial function, either alone, or in conjunction with other disease\u2010modifying agents may halt or slow the progression of neurodegeneration in Parkinson's disease.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15154-fig-0004-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15154","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T12:16:14Z","timestamp":1597580174000},"page":"715-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["The multi\u2010faceted role of mitochondria in the pathology of Parkinson\u2019s disease"],"prefix":"10.1111","volume":"156","author":[{"given":"Dennison","family":"Trinh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Toronto Scarborough Centre for Neurobiology of Stress Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad R.","family":"Israwi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Toronto Scarborough Centre for Neurobiology of Stress Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay R.","family":"Arathoon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Toronto Scarborough Centre for Neurobiology of Stress Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Gleave","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Toronto Scarborough Centre for Neurobiology of Stress Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5272-9034","authenticated-orcid":false,"given":"Joanne E.","family":"Nash","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Toronto Scarborough Centre for Neurobiology of Stress Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20456"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010014\u20109043\u20108"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.114"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.620906"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000605"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06228.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2008.06356.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.03.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703219104"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)31585\u20104"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","unstructured":"Auld G. 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