{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:49:12Z","timestamp":1790804952420,"version":"4.1.0"},"reference-count":132,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Olfactory disorders have been increasingly reported in individuals infected with SARS\u2010CoV\u20102, the virus causing the coronavirus disease 2019 (COVID\u201019). Losing the sense of smell has a strong impact on the quality of life, since it may lead to malnutrition, weight loss, food poisoning, depression, and exposure to dangerous chemicals. Individuals who suffer from anosmia (inability to smell) also cannot sense the flavor of food, which is a combination of taste and smell. Interestingly, infected individuals have reported sudden loss of smell with no congested nose, as is frequently observed in common colds or other upper respiratory tract infections. These observations suggest that SARS\u2010CoV\u20102 infection leads to olfactory loss through a distinct mechanism, which is still unclear. This article provides an overview of olfactory loss and the recent findings relating to COVID\u201019. Possible mechanisms of SARS\u2010CoV\u20102\u2010induced olfactory loss are also discussed.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15197-fig-0003-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15197","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T19:23:35Z","timestamp":1600975415000},"page":"930-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Viral infection and smell loss: The case of COVID\u201019"],"prefix":"10.1111","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-1933","authenticated-orcid":false,"given":"Isaias","family":"Glezer","sequence":"first","affiliation":[{"name":"Department of Biochemistry UNIFESP Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo Rua Tres de Maio S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-2190","authenticated-orcid":false,"given":"Alexandre","family":"Bruni\u2010Cardoso","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-7023","authenticated-orcid":false,"given":"Deborah","family":"Schechtman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-4784","authenticated-orcid":false,"given":"Bettina","family":"Malnic","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2012.141280"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182275264"},{"key":"e_1_2_11_4_1","first-page":"1703","article-title":"Anosmia in COVID\u201019 associated with injury to the olfactory bulbs evident on MRI","volume":"41","author":"Aragao M.","year":"2020","journal-title":"AJNR. 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