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The regulatory role of a variety of microRNAs in PD has been confirmed, and our study is the first to demonstrate that miR\u20103473b is involved in the regulation of PD. In vitro, an miR\u20103473b inhibitor can inhibit the secretion of inflammatory factors (TNF\u2010\u03b1 and IL\u20101\u03b2) in moues microglia cell line (BV2) cells induced by lipopolysaccharide (LPS) and promote autophagy in BV2 cells. In vivo, miR\u20103473b antagomir can inhibit the activation of substantia nigra pars compacta (SNpc) microglia of C57BL\/6 mice induced by 1\u2010Methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) and promote autophagy. Deletion of TREM2, one of the most highly expressed receptors in microglia, leads to the occurrence and development of PD. ULK1 is a component of the Atg1 complex. Deletion of ULK1 aggravates the pathological reaction of PD. TREM2 and ULK1 are predicted potential targets of miR\u20103473b by Targetscan. Then, the results of our experiments indicate that transfection with a miR\u20103473b mimic can inhibit the expression of TREM2 and ULK1. Data from a double luciferase experiment indicate that the 3'\u2010UTR of TREM2, but not ULK1, is the direct target of miR\u20103473b. Then we aim to investigate the regulation of TREM2 and ULK1 in PD. We found that the expression of p\u2010ULK1 was significantly increased via up\u2010regulation of TREM2. The increased expression of p\u2010ULK1 can promote autophagy and inhibit the expression of inflammatory factors. The regulation of ULK1 by miR\u20103473b may be accomplished indirectly through TREM2. Thus, miR\u20103473b may regulate the secretion of proinflammatory mediators by targeting TREM2\/ULK1 expression to regulate the role of autophagy in the pathogenesis of inflammation in Parkinson's disease, suggesting that mir\u20103473b may be a potential therapeutic target to regulate the inflammatory response in PD.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15299-fig-0010-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15299","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:29:52Z","timestamp":1610753392000},"page":"599-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["MicroRNA\u20103473b regulates the expression of TREM2\/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson disease"],"prefix":"10.1111","volume":"157","author":[{"given":"Qiankun","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Neurology the Second Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurology the Second Affiliated Hospital of Nanchang University 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