{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:28:57Z","timestamp":1779233337157,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801274"],"award-info":[{"award-number":["81801274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The associations between obesity and Alzheimer's disease (AD) at different ages have been debated. Recent evidence implied the protective effects of metabolically healthy obesity on AD. We hypothesized that obesity and lipids could mitigate the detrimental impacts of AD pathological changes among metabolically healthy individuals in late life. In this study, a total of 604 metabolically healthy participants with normal cognition were included from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) database. Multiple linear regression models were used to test the associations of body mass index (BMI) or lipids with cerebrospinal fluid (CSF) biomarkers after adjustment for age, gender, education, and <jats:italic>Apolipoprotein E\u2010\u025b4<\/jats:italic> (<jats:italic>APOE<\/jats:italic>\u2010\u025b4). The results showed the lower CSF levels of total tau protein (t\u2010tau: <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0048) and phosphorylated tau protein (p\u2010tau: <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0035) in obese participants than in non\u2010obese participants, even after correcting for covariates. Moreover in late life, higher BMI was associated with decreased CSF t\u2010tau (\u03b2: \u22120.15, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0145) and p\u2010tau (\u03b2: \u22120.17, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0052). As for lipids, higher levels of total cholesterol (TC) and low\u2010density lipoprotein cholesterol (LDL\u2010C) were associated with decreased CSF t\u2010tau (TC: \u03b2: \u22120.16, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0115; LDL\u2010C: \u03b2: \u22120.16, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0082) and p\u2010tau (TC: \u03b2: \u22120.15, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0177; LDL\u2010C: \u03b2: \u22120.14, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0225) in obese participants. Furthermore, these associations were only significant in participants with late\u2010life obesity and <jats:italic>APOE\u2010<\/jats:italic>\u025b4 non\u2010carriers. Overall, in a cognitively normal population, we found metabolically healthy obesity and lipids in late life might be protective factors for neurodegenerative changes.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15306-fig-0004-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15306","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T18:43:26Z","timestamp":1610995406000},"page":"834-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Metabolically healthy obesity and lipids may be protective factors for pathological changes of alzheimer\u2019s disease in cognitively normal adults"],"prefix":"10.1111","volume":"157","author":[{"given":"Shu\u2010Juan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Lin","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Qingdao Municipal Hospital Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Ning","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology Huashan Hospital Shanghai Medical College Fudan University Shanghai 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