{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:07:03Z","timestamp":1791166023122,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11972099"],"award-info":[{"award-number":["11972099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600770"],"award-info":[{"award-number":["31600770"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The mechanisms of brain injury after intracerebral hemorrhage (ICH) involve mass effect\u2010induced primary injury and secondary injury caused by a pathologic response to the hematoma. Considerable attentions have recently been paid to the mechanisms and therapeutic strategy for secondary brain injury due to no overall benefit from early surgery compared with initial conservative treatment. However, it is unclear whether there is a causal relationship between mass effect and secondary brain injury. Here, the role of mass effect on early erythrolysis after experimental ICH was investigated based on the poly(<jats:italic>N<\/jats:italic>\u2010isopropylacrylamide) (PNIPAM) ICH model. Autologous blood and PNIPAM hydrogel were co\u2010injected into the right basal ganglia of rats to induce different degrees of mass effect, but with a constant hematoma. The influences of different mass effect and time courses on erythrolysis and brain damages after ICH were investigated. Furthermore, the protective effect of trehalose against erythrolysis after ICH was evaluated. The results showed that mass effect caused erythrocyte morphological change at 24\u00a0hr after ICH. The released hemoglobin was quantitatively evaluated by a polynomial concerning with the mass effect, the volume of hematoma, and the time of ICH. An obvious increase in heme oxygenase\u20101 (HO\u20101) and ionized calcium binding adaptor molecule\u20101 (Iba\u20101) expression, iron deposition, cell death, and neurological deficits was observed with increasing mass effect. Moreover, trehalose alleviated brain injury by inhibiting erythrolysis after ICH. These data demonstrated that mass effect accelerated the erythrolysis and brain damages after ICH, which could be relieved through trehalose therapy.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15361-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15361","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T12:44:53Z","timestamp":1617367493000},"page":"88-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of mass effect and trehalose on early erythrolysis after experimental intracerebral hemorrhage"],"prefix":"10.1111","volume":"160","author":[{"given":"Yuhua","family":"Gong","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Engineering Southwest University of Science and Technology  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Deng","sequence":"additional","affiliation":[{"name":"College of Environment and Resources Chongqing Technology and Business University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongkun","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing 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