{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:04:25Z","timestamp":1781132665865,"version":"3.54.1"},"reference-count":166,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GRP1162505"],"award-info":[{"award-number":["GRP1162505"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["Young Researcher Development Program"],"award-info":[{"award-number":["Young Researcher Development Program"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Cholinergic basal forebrain (cBF) neurons are particularly vulnerable to degeneration following trauma and in neurodegenerative conditions. One reason for this is their characteristic expression of the p75 neurotrophin receptor (p75<jats:sup>NTR<\/jats:sup>), which is up\u2010regulated and mediates neuronal death in a range of neurological and neurodegenerative conditions, including dementia, stroke and ischaemia. The signalling pathway by which p75<jats:sup>NTR<\/jats:sup> signals cell death is incompletely characterised, but typically involves activation by neurotrophic ligands and signalling through c\u2010Jun kinase, resulting in caspase activation via mitochondrial apoptotic signalling pathways. Less well appreciated is the link between conditions of oxidative stress and p75<jats:sup>NTR<\/jats:sup> death signalling. Here, we review the literature describing what is currently known regarding p75<jats:sup>NTR<\/jats:sup> death signalling in environments of oxidative stress and hypoxia to highlight the overlap in signalling pathways and the implications for p75<jats:sup>NTR<\/jats:sup> signalling in cBF neurons. We propose that there is a causal relationship and define key questions to test this assertion.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15451-fig-0004-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15451","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T19:08:07Z","timestamp":1623352087000},"page":"1292-1306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?"],"prefix":"10.1111","volume":"158","author":[{"given":"Kornraviya","family":"Sankorrakul","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences Faculty of Medicine and Queensland Brain Institute Clem Jones Centre for Ageing Dementia Research The University of Queensland Brisbane Qld. Australia"},{"name":"Research Center for Neuroscience Institute of Molecular Biosciences Mahidol University Salaya Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3480-4248","authenticated-orcid":false,"given":"Lei","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences Faculty of Medicine and Queensland Brain Institute Clem Jones Centre for Ageing Dementia Research The University of Queensland Brisbane Qld. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wipawan","family":"Thangnipon","sequence":"additional","affiliation":[{"name":"Research Center for Neuroscience Institute of Molecular Biosciences Mahidol University Salaya Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-6197","authenticated-orcid":false,"given":"Elizabeth J.","family":"Coulson","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences Faculty of Medicine and Queensland Brain Institute Clem Jones Centre for Ageing Dementia Research The University of Queensland Brisbane Qld. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/life10070101"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.6.1691"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0591-15.2015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv024"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.4.911"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00011-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6501"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20191106"},{"key":"e_1_2_11_10_1","first-page":"8","article-title":"Intracellular accumulation of amyloid\u2010\u03b2: A predictor for synaptic dysfunction and neuron loss in Alzheimer's disease","volume":"2","author":"Bayer T. A.","year":"2010","journal-title":"Frontiers in Aging Neuroscience"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818781930"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200609074"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-36-11373.2003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04496.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2364-14.2014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/NS20180066"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0248-x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.07.023"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00400.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz224"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/383716a0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.21.6050"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.15.6415-6426.2005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001914200"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200694200"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00132"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.07.048"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14587"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181219298"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:25:2:141"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2699-07.2008"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005214200"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.23.16387"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)46003-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.4.263"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.04.041"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202614999"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1102-1131"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.05.007"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.838205"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152677"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.11.005"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00008-8"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42420-6"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311401"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/428010"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)46002-0"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-805417-8.00004-4"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6789"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-019-00755-2"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00928-X"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.015032"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21445"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.05.001"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu193"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01100.x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00156.2002"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305755101"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14970"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.01.030"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.24.9361-9374.2003"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.677"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.03.007"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33928"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1982-13.2014"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306028200"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-13-05425.2003"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-019-01905-w"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.082834"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.011"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:12:1:1"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-16-05854.2001"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0620-09.2009"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07120.x"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.11.036"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.563403"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308454200"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00028.2010"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.11.5.19436"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.033"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-04-02888.1995"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.16.4999"},{"key":"e_1_2_11_83_1","first-page":"3459","article-title":"Correlation research on the protein expression (p75NTR, bax, bcl\u20102, and caspase\u20103) and cortical neuron apoptosis following mechanical injury in rat","volume":"19","author":"Liu H. C.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2002.00744.x"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0150-7"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.05.003"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.173864"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00455"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20170002"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.05.019"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-014-9566-9"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06137.x"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvs006"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160044"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5368"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000140200"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092880"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2012.669041"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.02.024"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02319"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2363"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1162\/153840902753658329"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0583-x"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00252"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.89"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0180-4"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02357.x"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0823-07.2007"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90473-1"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011797"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302376200"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3026"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr313"},{"key":"e_1_2_11_114_1","first-page":"1","article-title":"Cholinergic basal forebrain degeneration due to obstructive sleep apnoea increases Alzheimer's pathology in mice","author":"Qian L.","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4806-06.2007"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.09.012"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1894"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00016-3"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.11.028"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-09-03597.2003"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00036-2"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205324200"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13932"},{"key":"e_1_2_11_124_1","first-page":"684","article-title":"Increased levels of reactive oxygen species in brain slices after transient hypoxia induced by a reduced oxygen supply","volume":"8","author":"Sasaki T.","year":"2018","journal-title":"Neuropsychiatry (London)"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.11.058"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01304.x"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.04.062"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00194-0"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.021"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.09.025"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14609"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2510-y"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.002"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.02.020"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394447-4.30011-6"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201100036"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0350-08.2008"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi401719r"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2019.109249"},{"key":"e_1_2_11_140_1","first-page":"1","volume-title":"Handbook of clinical neurology","author":"Swaab D. F.","year":"2003"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-01-j0006.2000"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01162"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4536-15.2016"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbscr.2016.03.001"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.05.021"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx120"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205167200"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10703"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2005.00160.x"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.10.005"},{"key":"e_1_2_11_151_1","first-page":"269","article-title":"Stimulation of nerve growth factor expression in astrocytes by peroxynitrite","volume":"18","author":"Vargas M. R.","year":"2004","journal-title":"Vivo (Athens, Greece)"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.161745"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.055061"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.02.020"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.07.028"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5510"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02444"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00169"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00844.x"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119772"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003604"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.42.30202"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1390-04.2004"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3091424"},{"key":"e_1_2_11_165_1","first-page":"447","article-title":"p75NTR\u2010dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade","volume":"128","author":"Zeinieh M.","year":"2015","journal-title":"Journal of Cell Science"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2212-2"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.15451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:58:55Z","timestamp":1693295935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.15451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,5]]},"references-count":166,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/jnc.15451"],"URL":"https:\/\/doi.org\/10.1111\/jnc.15451","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,5]]},"assertion":[{"value":"2020-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}