{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:51:16Z","timestamp":1758815476396,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Various neuroimaging approaches have reported alterations in brain connectivity in patients with autism spectrum disorder (ASD). Nevertheless, specific cellular and molecular mechanisms underlying these alterations remain to be elucidated. In the present Editorial, we highlight an article in the current issue of the <jats:italic>Journal of Neurochemistry<\/jats:italic> that provides first evidence for the structural and cellular basis of an atypical corpus callosum long\u2010distance connectivity impairments observed in ASD patients. The authors used a juvenile valproic acid (VPA) rat model of ASD that presents with reduced myelin level, specifically in the corpus callosum, and with an altered myelin sheet structure that is closely associated with the behavioral alteration found in these rats. This hypomyelination occurs primarily during infancy prior to oligodendroglial alterations, implicating that axonal\u2010oligodendroglial connections are compromised in this model. Concomitant with the hypomyelination, the ASD rat model showed an atypical brain metabolic pattern, with hypometabolic activity across the whole brain, and hypermetabolism in brain areas related to autistic\u2010like behavior. These findings contribute to unravel the neurobiological basis underlying white matter alteration and altered long\u2010distance brain connectivity as described in ASD, paving the way to the development of new early diagnostic markers and toward developing future specific therapies for ASD.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15452-fig-0002-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15452","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T17:41:25Z","timestamp":1626111685000},"page":"12-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Another step toward understanding brain functional connectivity alterations in autism"],"prefix":"10.1111","volume":"159","author":[{"given":"Federica","family":"Giona","sequence":"first","affiliation":[{"name":"CNR Neuroscience Institute Milano Italy"},{"name":"NeuroMI Milan Center for Neuroscience University of Milano\u2010Bicocca Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Pagano","sequence":"additional","affiliation":[{"name":"CNR Neuroscience Institute Milano Italy"},{"name":"NeuroMI Milan Center for Neuroscience University of Milano\u2010Bicocca Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Verpelli","sequence":"additional","affiliation":[{"name":"CNR Neuroscience Institute Milano Italy"},{"name":"NeuroMI Milan Center for Neuroscience University of Milano\u2010Bicocca Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-9523","authenticated-orcid":false,"given":"Carlo","family":"Sala","sequence":"additional","affiliation":[{"name":"CNR Neuroscience Institute Milano Italy"},{"name":"NeuroMI Milan Center for Neuroscience University of Milano\u2010Bicocca Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.03.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.78"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175870"},{"key":"e_1_2_6_6_1","first-page":"208","article-title":"Role of the corpus callosum in functional connectivity","volume":"24","author":"Quigley M.","year":"2003","journal-title":"AJNR. 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