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Spontaneously occurring dopamine release was compared across these subregions. Dopamine release\/uptake dynamics differ across striatal subregions, with dopamine transient release amplitude and release frequency greatest in male mice, and the largest signals observed in the DS. Surprisingly, female mice exhibited little regional differences in dopamine release for DS and nucleus accumbens core regions, but lower release in the nucleus accumbens shell. Blocking voltage\u2010gated K<jats:sup>+<\/jats:sup> channel (Kv channels) with 4\u2010aminopyridine enhanced dopamine detection without affecting reuptake. The 4\u2010aminopyridine effects were greatest in ventral regions of female mice, suggesting regional differences in Kv channel expression. The dopamine transporter blocker cocaine also enhanced detection across subregions in both sexes, with greater overall increased release in females than males. Thus, sex differences in dopamine transmission are apparent and likely include differences in the Kv channel and dopamine transporter function. The lack of regional differences in dopamine release observed in females indicates differential regulation of spontaneous and evoked dopamine release.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15473-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15473","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T19:52:08Z","timestamp":1626378728000},"page":"598-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Regional and sex differences in spontaneous striatal dopamine transmission"],"prefix":"10.1111","volume":"160","author":[{"given":"James N.","family":"Brundage","sequence":"first","affiliation":[{"name":"Neuroscience Center Brigham Young University  Provo UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Mason","sequence":"additional","affiliation":[{"name":"Neuroscience Center Brigham Young University  Provo UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary A.","family":"Wadsworth","sequence":"additional","affiliation":[{"name":"Neuroscience Center Brigham Young University  Provo UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris S.","family":"Finuf","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Center Brigham Young University  Provo UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh J.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Neuroscience Center Brigham Young University  Provo UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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