{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:24:08Z","timestamp":1771590248870,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971140"],"award-info":[{"award-number":["81971140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>We investigated the serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels in a cohort of Chinese patients with neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) in relation to clinical disease course and treatment. sNfL and sGFAP levels were determined by ultrasensitive single molecule array (Simoa) assay in patients with NMOSD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0102) and MS (<jats:italic>n<\/jats:italic>\u00a0=\u00a098) and healthy controls (HCs; <jats:italic>n<\/jats:italic>\u00a0=\u00a084). Notably, 13 patients with NMOSD and 27 patients with MS were enrolled in the 1\u2010year follow\u2010up cohort. Levels were compared with data such as clinical course, disease duration, Expanded Disability Status Scale (EDSS) score, and lesions on MRI. Higher levels of sNfL and sGFAP were found in subjects with NMOSD and MS than in HCs (sNfL, median 12.11, 17.5 vs. 8.88\u00a0pg\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05; sGFAP, median 130.2, 160.4 vs. 80.01\u00a0pg\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Moreover, sNfL levels were higher in the relapse phase of MS than in the relapse phase of NMOSD (30.02 vs. 14.57\u00a0pg\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05); sGFAP levels were higher in the remission phase of MS than in the remission phase of NMOSD (159.8 vs. 124.5\u00a0pg\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). A higher sGFAP\/sNfL quotient at relapse differentiated NMOSD from MS. Multivariate analyses indicated that sGFAP levels were associated with the EDSS score in NMOSD (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). At the 1\u2010year follow\u2010up, sNfL and sGFAP levels were both decreased in NMOSD patients in remission, while only sNfL levels were decreased in MS patients in remission. sGFAP and sNfL are potential blood biomarkers for diagnosing and monitoring NMOSD and MS.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15478-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15478","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T07:09:07Z","timestamp":1626678547000},"page":"913-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Serum neurofilament light chain and glial fibrillary acidic protein in AQP4\u2010IgG\u2010seropositive neuromyelitis optica spectrum disorders and multiple sclerosis: A cohort study"],"prefix":"10.1111","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-0605","authenticated-orcid":false,"given":"Chunxin","family":"Liu","sequence":"first","affiliation":[{"name":"Neurology Department The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Emergency Department The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxin","family":"Lu","sequence":"additional","affiliation":[{"name":"Clinical Data Center The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurology Department The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyu","family":"Chang","sequence":"additional","affiliation":[{"name":"Neurology Department The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuge","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurology Department The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Neurology Department The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Data Center The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-4016","authenticated-orcid":false,"given":"Allan G.","family":"Kermode","sequence":"additional","affiliation":[{"name":"Neurology Department The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Perron Institute University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongbiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emergency Department The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0880-958X","authenticated-orcid":false,"given":"Wei","family":"Qiu","sequence":"additional","affiliation":[{"name":"Neurology Department The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 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