{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:35:24Z","timestamp":1775295324793,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T00:00:00Z","timestamp":1630195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Studies have verified that Fragile X mental retardation protein (FMRP), an RNA\u2010binding protein, plays a potential role in the pathogenesis of formalin\u2010 and (RS)\u20103,5\u2010dihydroxyphenylglycine\u2010induced abnormal pain sensations. However, the role of FMRP in inflammatory pain has not been reported. Here, we showed an increase in FMRP expression in the spinal dorsal horn (SDH) in a rat model of inflammatory pain induced by complete Freund's adjuvant (CFA). Double immunofluorescence staining revealed that FMRP was mainly expressed in spinal neurons and colocalized with proinflammatory cytokines [tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u20106 (IL\u20106)]. After consecutive intrathecal injection of fragile X mental retardation 1 small interfering RNA for 3\u00a0days post\u2010CFA injection, FMRP expression in the SDH was reduced, and CFA\u2010induced hyperalgesia was decreased. In addition, the CFA\u2010induced increase in spinal TNF\u2010\u03b1 and IL\u20106 production was significantly suppressed by intrathecal administration of fragile X mental retardation 1 small interfering RNA. Together, these results suggest that FMRP regulates TNF\u2010\u03b1 and IL\u20106 levels in the SDH and plays an important role in inflammatory pain.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15485-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15485","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T10:46:10Z","timestamp":1627901170000},"page":"512-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fragile X mental retardation protein\u2010regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory 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