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Mast cells (MCs) participate in numerous inflammatory processes through the release of important amounts of histamine (HA). In this study, we aimed to characterize the participation of MCs and HA in the establishment of neural and oxidative damage in the QUIN\u2010induced model of HD. C57BL6\/J mice (WT), MC\u2010deficient <jats:italic>c\u2010Kit<jats:sup>W\u2010sh\/W\u2010sh<\/jats:sup><\/jats:italic> (Wsh) mice and Wsh mice reconstituted by intracerebroventricular (i.c.v.) injection of 5\u00a0\u00d7\u00a010<jats:sup>5<\/jats:sup> bone marrow\u2010derived mast cells (BMMCs), or i.c.v. administered with HA (5\u00a0\u00b5g) were used. All groups of animals were intrastriatally injected with 1\u00a0\u00b5L QUIN (30\u00a0nmol\/\u00b5L) and 3\u00a0days later, apomorphine\u2010induced circling behavior, striatal GABA levels and the number of Fluoro\u2010Jade positive cells, as indicators of neuronal damage, were determined. Also, lipid peroxidation (LP) and reactive oxygen species production (ROS), as markers of oxidative damage, were analyzed. Wsh mice showed less QUIN\u2010induced neuronal and oxidative damage than WT and Wsh\u2010MC reconstituted animals. Histamine administration restored the QUIN\u2010induced neuronal and oxidative damage in the non\u2010reconstituted Wsh mice to levels equivalent or superior to those observed in WT mice. Our results demonstrate that MCs and HA participate in the neuronal and oxidative damages observed in mice subjected to the QUIN \u2010induced model of Huntington's disease.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15527-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15527","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T21:30:01Z","timestamp":1634765401000},"page":"256-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid\u2010induced model of Huntington's disease"],"prefix":"10.1111","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-5100","authenticated-orcid":false,"given":"Pablo Eliasib","family":"Mart\u00ednez\u2010Gopar","sequence":"first","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN (Cinvestav) Unidad Sede Sur  Ciudad de Mexico Mexico"},{"name":"Laboratorio de Neurofarmacolog\u00eda Molecular y Nanotecnolog\u00eda Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-0320","authenticated-orcid":false,"given":"Marian Jesabel","family":"P\u00e9rez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacobiolog\u00eda Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN (Cinvestav) Unidad Sede Sur  Ciudad de Mexico Mexico"},{"name":"Laboratorio de 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