{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:01Z","timestamp":1787015581549,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Alcohol\u2010related brain injury is characterized by cognitive deficits and brain atrophy with the prefrontal cortex particularly susceptible. White matter in the human brain is lipid rich and a major target of damage from chronic alcohol abuse; yet, there is sparse information on how these lipids are affected. Here, we used untargeted lipidomics as a discovery tool to describe these changes in the prefrontal, middle temporal, and visual cortices of human subjects with alcohol use disorder and controls. Significant changes to the lipidome, predominantly in the prefrontal and visual cortices, and differences between the white and grey matter of each brain region were identified. These effects include broad decreases to phospholipids and ceramide, decreased polyunsaturated fatty acids, decreased sphingadiene backbones, and selective decreases in cholesteryl ester fatty acid chains. Our findings show that chronic alcohol abuse results in selective changes to the neurolipidome, which likely reflects both the directs effects on the brain and concurrent effects on the liver.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15530-fig-0010-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jnc.15530","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T16:16:48Z","timestamp":1635265008000},"page":"271-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Lipidome changes in alcohol\u2010related brain damage"],"prefix":"10.1111","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-390X","authenticated-orcid":false,"given":"Caine C.","family":"Smith","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health School of Medical Sciences and Charles Perkins Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna L.","family":"Sheedy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health School of Medical Sciences and Charles Perkins Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly P.","family":"McEwen","sequence":"additional","affiliation":[{"name":"Centenery Institute The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-1184","authenticated-orcid":false,"given":"Anthony S.","family":"Don","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health School of Medical Sciences and Charles Perkins Centre The University of Sydney  Sydney New South Wales Australia"},{"name":"Centenery Institute The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian J.","family":"Kril","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health School of Medical Sciences and Charles Perkins Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-9736","authenticated-orcid":false,"given":"Greg T.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health School of Medical Sciences and Charles Perkins Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3820"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.01.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10060236"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2017.08.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010013\u20101233\u20103"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25715"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010013\u20109469\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038607"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2010.01283.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds432"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010007\u20100050\u20103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.08.030"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20101063(1997)7:1<78:AID\u2010HIPO8>3.0.CO;2\u20103"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6467.501"},{"key":"e_1_2_10_16_1","first-page":"401","article-title":"Physical properties and lipid composition of brain membranes from ethanol tolerant\u2010dependent mice","volume":"25","author":"Harris R. A.","year":"1984","journal-title":"Molecular Pharmacology"},{"key":"e_1_2_10_17_1","first-page":"461","article-title":"Effects of ethanol and related drugs on the physical and functional properties of brain membranes","volume":"8","author":"Harris R. A.","year":"1981","journal-title":"Currents in Alcoholism"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301332"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600396-JLR200"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(73)91092\u20101"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328342991c"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2007.00442.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01991778"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306\u20104522(97)00083\u20103"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294379"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs174"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2017.09.017"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D700041\u2010JLR200"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2016.04.002"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40474\u2010014\u20100020\u20108"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.003970"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000190"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2001.tb02340.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150916"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20102275(20)39619\u2010X"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13943"},{"key":"e_1_2_10_37_1","first-page":"165","article-title":"The differential effects of alcohol and nicotine\u2010specific nitrosamine ketone on white matter ultrastructure","volume":"52","author":"Papp\u2010Peka A.","year":"2017","journal-title":"Alcohol and Alcoholism"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.062364"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105999"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20102275(20)31629\u20101"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109150(94)90107\u20104"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00120"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn500174c"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2005.04.011"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10110438"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008933"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-62619-6.00035-5"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2016.02.005"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002804"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2011.01559.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13197"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2019.05.010"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6485.1859"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20104157(96)00010\u2010X"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20102275(20)30268\u20106"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415596202"},{"key":"e_1_2_10_57_1","first-page":"183","article-title":"Alcohol's effects on the brain: neuroimaging results in humans and animal models","volume":"38","author":"Zahr N. M.","year":"2017","journal-title":"Alcohol Research"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010017\u20100558\u20105"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.15530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T17:27:13Z","timestamp":1692206833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.15530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,11]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/jnc.15530"],"URL":"https:\/\/doi.org\/10.1111\/jnc.15530","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,11]]},"assertion":[{"value":"2020-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}