{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:16:23Z","timestamp":1775985383047,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T00:00:00Z","timestamp":1638662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016\u20100170"],"award-info":[{"award-number":["PICT 2016\u20100170"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2017\u20101736"],"award-info":[{"award-number":["PICT 2017\u20101736"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PIP\u20102012"],"award-info":[{"award-number":["PIP\u20102012"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The nervous system monitors the environment to maintain homeostasis, which can be affected by stressful conditions. Using mammalian models of chronic stress, we previously observed altered brain levels of GPM6A, a protein involved in neuronal morphology. However, GPM6A's role in systemic stress responses remains unresolved. The nematode <jats:italic>Caenorhabditis elegans<\/jats:italic> expresses a GPM6A ortholog, the neuronal membrane glycoprotein 1 (NMGP\u20101). Because of the shared features between nematode and mammalian nervous systems and the vast genetic tools available in <jats:italic>C<\/jats:italic>. <jats:italic>elegans<\/jats:italic>, we used the worm to elucidate the role of GPM6A in the stress response. We first identified <jats:italic>nmgp<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> expression in different amphid and phasmid neurons. To understand the <jats:italic>nmgp<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> role, we characterized the behavior of <jats:italic>nmgp<\/jats:italic>\u2010<jats:italic>1(RNAi)<\/jats:italic> animals and two <jats:italic>nmgp<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> mutant alleles. Compared to control animals, mutant and RNAi\u2010treated worms exhibited increased recovery time from the stress\u2010resistant dauer stage, altered SDS chemosensation and reduced egg\u2010laying rate resulting in egg retention (bag\u2010of\u2010worms phenotype). Silencing of <jats:italic>nmgp<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> expression induced morphological abnormalities in the ASJ sensory neurons, partly responsible for dauer exit. These results indicate that <jats:italic>nmgp<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> is required for neuronal morphology and for behaviors associated with chemosensation. Finally, we propose <jats:italic>nmgp<\/jats:italic>\u2010<jats:italic>1<\/jats:italic>\u00a0mutants as a tool to screen drugs for human nervous system pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15543-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.15543","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T08:55:45Z","timestamp":1637744145000},"page":"234-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>Neuronal membrane glycoprotein (nmgp\u20101)<\/i> gene deficiency affects chemosensation\u2010related behaviors, dauer exit and egg\u2010laying in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1111","volume":"160","author":[{"given":"Eliana M.","family":"Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas Universidad Nacional de San Mart\u00edn (UNSAM) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) San Mart\u00edn  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamila B.","family":"Cutraro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas Universidad Nacional de San Mart\u00edn (UNSAM) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) San Mart\u00edn  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Adams","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Illinois State University  Normal Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melisa C.","family":"Monteleone","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas Universidad Nacional de San Mart\u00edn (UNSAM) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) San Mart\u00edn  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiley J.","family":"Hughes","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Illinois State University  Normal Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto C.","family":"Frasch","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas Universidad Nacional de San Mart\u00edn (UNSAM) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) San Mart\u00edn  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s G.","family":"Vidal\u2010Gadea","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Illinois State University  Normal Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-0814","authenticated-orcid":false,"given":"Marcela A.","family":"Brocco","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas Universidad Nacional de San Mart\u00edn (UNSAM) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) San Mart\u00edn  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1976.0085"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504262102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.036"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03178.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.01.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-7-61"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)80053\u2010H"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2006412"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167\u20107799(01)01925\u20104"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001499"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30667"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007896"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.07064.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn435"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10158\u2010011\u20100126\u20101"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1463"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8940"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3399\u201005.2005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506806103"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.06.027"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704975104"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485423"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.28"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22298"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23482"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13153"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.04.057"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.012377"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.01.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.01.018"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.07.042"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10014"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00813-8"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2144\/02324bm01"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2512-2"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1895\/wormbook.1.144.1"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1811379116"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/01677063.2020.1823386"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","unstructured":"Karp X.(2018)Working with dauer larvae WormBook ed. The C. elegans Research Community WormBook doi\/10.1895\/ wormbook.1.180.1 http:\/\/www.wormbook.org","DOI":"10.1895\/wormbook.1.180.1"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/157.4.1599"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.118.301307"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4315"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480230108"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.10.5.703"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710374114"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1795"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0088"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.25925"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09713-0"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02284-2"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(02)00653\u20100"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi500317h"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6807-9-51"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02070"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3791\/4019"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh377"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.40.110405.090527"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.10.007"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)81068\u20105"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020085"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01955"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70135-6"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04002.2000"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-s1-s12"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/104.4.619"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000638"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn100010p"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1986.0056"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960708)370:4<465::AID-CNE4>3.0.CO;2-2"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.012"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002082"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102202\u201013\u201078"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019715"},{"key":"e_1_2_10_76_1","first-page":"1623","article-title":"M6a is expressed in the murine neural retina and regulates neurite extension","volume":"14","author":"Zhao J.","year":"2008","journal-title":"Molecular Vision"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnc.15543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T21:27:16Z","timestamp":1692221236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.15543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,5]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/jnc.15543"],"URL":"https:\/\/doi.org\/10.1111\/jnc.15543","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,5]]},"assertion":[{"value":"2021-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}