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Their broad therapeutic potential might result from an ability to rescue cortical atrophy common to many neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor gene expression, activating neuronal growth and survival mechanisms, and modulating the immune system. While the therapeutic potential of psychedelics has not yet been extended to neurodegenerative disorders, we provide evidence suggesting that approaches based on psychedelic science might prove useful for treating these diseases. The primary target of psychedelics, the 5\u2010HT\n                      <jats:sub>2A<\/jats:sub>\n                      receptor, plays key roles in cortical neuron health and is dysregulated in Alzheimer's disease. Moreover, evidence suggests that psychedelics and related compounds could prove useful for treating the behavioral and psychological symptoms of dementia (BPSD). While more research is needed to probe the effects of psychedelics in models of neurodegenerative diseases, the robust effects of these compounds on structural and functional neuroplasticity and inflammation clearly warrant further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15544-fig-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jnc.15544","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T03:58:32Z","timestamp":1637726312000},"page":"109-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Psychedelic\u2010inspired approaches for treating neurodegenerative disorders"],"prefix":"10.1111","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3055-5547","authenticated-orcid":false,"given":"Hannah N.","family":"Saeger","sequence":"first","affiliation":[{"name":"Pharmacology and Toxicology Graduate Group University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-0543","authenticated-orcid":false,"given":"David E.","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of California, Davis  Davis California USA"},{"name":"Department of Biochemistry &amp; Molecular Medicine School of Medicine University of California, Davis  Sacramento California USA"},{"name":"Center for Neuroscience University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,5]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00051-8"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.004"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23265"},{"issue":"21","key":"e_1_2_15_5_1","first-page":"00157","article-title":"Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics","volume":"0165","author":"Aleksandrova L. 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