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On the other hand, High\u2010Density Lipoproteins (HDL) cholesterol levels have been associated with reduced brain amyloidosis and improved cognitive function. However, recent findings have suggested that HDL\u2010functionality, which depends upon the HDL\u2010cargo proteins associated with HDL, rather than HDL levels, appears to be the key factor, suggesting a quality over quantity status. In this report, we have assessed the HDL\u2010cargo (Cholesterol, ApoA\u2010I, ApoA\u2010II, ApoC\u2010I, ApoC\u2010III, ApoD, ApoE, ApoH, ApoJ, CRP, and SAA) in stable healthy control (HC), healthy controls who will convert to MCI\/AD (HC\u2010Conv) and AD patients (AD). Compared to HC we observed an increased cholesterol\/ApoA\u2010I ratio in AD and HC\u2010Conv, as well as an increased ApoD\/ApoA\u2010I ratio and a decreased ApoA\u2010II\/ApoA\u2010I ratio in AD. Higher cholesterol\/ApoA\u2010I ratio was also associated with lower cortical grey matter volume and higher ventricular volume, while higher ApoA\u2010II\/ApoA\u2010I and ApoJ\/ApoA\u2010I ratios were associated with greater cortical grey matter volume (and for ApoA\u2010II also with greater hippocampal volume) and smaller ventricular volume. Additionally, in a clinical status\u2010independent manner, the ApoE\/ApoA\u2010I ratio was significantly lower in APOE \u03b54 carriers and lowest in APOE \u03b54 homozygous. Together, these data indicate that in AD patients the composition of HDL is altered, which may affect HDL functionality, and such changes are associated with altered regional brain volumetric data.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15681-fig-0004-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1111\/jnc.15681","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T20:51:57Z","timestamp":1659214317000},"page":"53-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Plasma high\u2010density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain 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