{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:48:00Z","timestamp":1781920080880,"version":"3.54.5"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["Z1A DA000611"],"award-info":[{"award-number":["Z1A DA000611"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While the illicit use and misuse of stimulants like cocaine and methylphenidate (MP) has increased, there remains no FDA\u2010approved treatments for psychostimulant use disorders (PSUD). Oxytocin (OT) has shown promise as a potential pharmacotherapy for PSUD. Dopamine (DA) neurotransmission plays a significant role in PSUD. We have recently shown that OT blunts the reinforcing effects of MP but, surprisingly, enhanced MP\u2010induced stimulation of DA levels. Such effects have been suggested as a result of activation of OT receptors or, alternatively, could be mediated by direct actions of OT on MP blockade of the DA transporter. Here, we employed fast scan cyclic voltammetry (FSCV) to investigate the effects of systemic OT on MP\u2010induced changes in the dynamics of DA, phasic release and uptake, in the nucleus accumbens shell (NAS) of Sprague\u2013Dawley rats. We also tested the systemic effects of an antagonist of OT receptors, atosiban, to counteract the OT enhancement of dopaminergic effects of MP under microdialysis procedures in the NAS in rats. Administration of OT alone (2\u00a0mg\/kg; i.p.) did not significantly modify evoked NAS DA dynamics measured by FSCV, and when administered 10\u00a0min before MP (0.1, 0.3, 1.0\u00a0mg\/kg; i.v.), OT did not potentiate MP\u2010induced increases in phasic DA release and did not alter DA clearance rate, suggesting no direct interactions of OT with the MP\u2010induced blockade of DA uptake. Also, OT alone did not elicit significant changes in tonic, extracellular NAS DA levels measured by microdialysis. However, consistent with previous studies, we observed that OT pretreatments (2\u00a0mg\/kg; i.p.) potentiated MP\u2010induced (0.1, 0.3, 1.0\u00a0mg\/kg; i.v.) efflux of extracellular NAS DA levels. This effect was abolished when rats were pretreated with atosiban (2\u00a0mg\/kg; i.p.), suggesting that OT receptors mediate this OT action. Overall, our results suggest that OT receptors mediated OT potentiation of MP\u2010induced stimulation of extracellular NAS DA levels, likely driven by modulation of DA receptor signaling pathways, without affecting MP blockade of DAT.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15730-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1111\/jnc.15730","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:25:47Z","timestamp":1669296347000},"page":"613-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oxytocin receptors mediate oxytocin potentiation of methylphenidate\u2010induced stimulation of accumbens dopamine in rats"],"prefix":"10.1111","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-9874","authenticated-orcid":false,"given":"Melinda","family":"Hersey","sequence":"first","affiliation":[{"name":"Medication Development Program NIDA IRP Maryland Baltimore USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda K.","family":"Bacon","sequence":"additional","affiliation":[{"name":"Medication Development Program NIDA IRP Maryland Baltimore USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia G.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Medication Development Program NIDA IRP Maryland Baltimore USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center District of Columbia Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy 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