{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:18:18Z","timestamp":1792275498364,"version":"4.4.0"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spreading depolarization (SD) is assumed to be the pathophysiological correlate of migraine aura, leading to spreading depression of activity and a long\u2010lasting vasoconstriction known as spreading oligemia. Furthermore, cerebrovascular reactivity is reversibly impaired after SD. Here, we explored the progressive restoration of impaired neurovascular coupling to somatosensory activation during spreading oligemia. Also, we evaluated whether nimodipine treatment accelerated the recovery of impaired neurovascular coupling after SD. Male, 4\u20139\u2010month\u2010old C57BL\/6 mice (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) were anesthetized with isoflurane (1%\u20131.5%), and SD was triggered with KCl through a burr hole made at the caudal parietal bone. EEG and cerebral blood flow (CBF) were recorded minimally invasively with a silver ball electrode and transcranial laser\u2010Doppler flowmetry, rostral to SD elicitation. The L\u2010type voltage\u2010gated Ca<jats:sup>2+<\/jats:sup> channel blocker nimodipine was administered i.p. (10\u00a0mg\/kg). Whisker stimulation\u2010related evoked potentials (EVPs) and functional hyperemia were assessed under isoflurane (0.1%)\u2013medetomidine (0.1\u00a0mg\/kg\u2009i.p.) anesthesia before, and repeatedly after SD, at 15\u2010min intervals for 75\u2009minutes. Nimodipine accelerated the recovery of CBF from spreading oligemia (time to full recovery, 52\u2009\u00b1\u200913 vs. 70\u2009\u00b1\u20098\u00a0min, nimodipine vs. control) and exhibited a tendency to shorten the duration of the SD\u2010related EGG depression duration. The amplitudes of EVP and functional hyperemia were markedly reduced after SD, and progressively recovered over an hour post\u2010SD. Nimodipine exerted no impact on EVP amplitude but consistently increased the absolute level of functional hyperemia from 20\u2009min post\u2010CSD (93\u2009\u00b1\u200911% vs. 66\u2009\u00b1\u200913%, nimodipine vs. control). A linear, positive correlation between EVP and functional hyperemia amplitude was skewed by nimodipine. In conclusion, nimodipine facilitated CBF restoration from spreading oligemia and the recovery of functional hyperemia post\u2010SD, which were linked to a tendency of an accelerated return of spontaneous neural activity after SD. The use of nimodipine in migraine prophylaxis is suggested to be re\u2010visited.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15792-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1111\/jnc.15792","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T12:34:48Z","timestamp":1677069288000},"page":"888-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia"],"prefix":"10.1111","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-3208","authenticated-orcid":false,"given":"\u00c1kos","family":"Menyh\u00e1rt","sequence":"first","affiliation":[{"name":"Hungarian Centre of Excellence for Molecular Medicine\u2014University of Szeged Cerebral Blood Flow and Metabolism Research Group  Szeged Hungary"},{"name":"Department of Cell Biology and Molecular Medicine, Albert Szent\u2010Gy\u00f6rgyi Medical School and Faculty of Science and Informatics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand Rafael","family":"B\u00e1lint","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Albert Szent\u2010Gy\u00f6rgyi Medical School and Faculty of Science and Informatics University of Szeged  Szeged Hungary"},{"name":"Department of Medical Physics and Informatics, Albert Szent\u2010Gy\u00f6rgyi Medical School and Faculty of Science and Informatics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Koz\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Albert Szent\u2010Gy\u00f6rgyi Medical School and Faculty of Science and Informatics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Bari","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, Albert Szent\u2010Gy\u00f6rgyi Medical School and Faculty of Science and Informatics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8478-9664","authenticated-orcid":false,"given":"Eszter","family":"Farkas","sequence":"additional","affiliation":[{"name":"Hungarian Centre of Excellence for Molecular Medicine\u2014University of Szeged Cerebral Blood 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