{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:07:07Z","timestamp":1791929227941,"version":"4.3.4"},"reference-count":172,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["39337\/2016\u20100"],"award-info":[{"award-number":["39337\/2016\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["88887.717239\/2022\u201000"],"award-info":[{"award-number":["88887.717239\/2022\u201000"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/50891\u20101 INCT 2014 \u2010 Translational Medicine"],"award-info":[{"award-number":["2014\/50891\u20101 INCT 2014 \u2010 Translational Medicine"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/02413\u20101"],"award-info":[{"award-number":["2017\/02413\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/08287\u20103"],"award-info":[{"award-number":["2019\/08287\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/09207\u20103"],"award-info":[{"award-number":["2019\/09207\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/13112\u20108"],"award-info":[{"award-number":["2019\/13112\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/01107\u20107"],"award-info":[{"award-number":["2020\/01107\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/00527\u20108"],"award-info":[{"award-number":["2022\/00527\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/03297\u20103"],"award-info":[{"award-number":["2022\/03297\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP\u20102018\u201001\u20109494"],"award-info":[{"award-number":["IP\u20102018\u201001\u20109494"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The renin\u2010angiotensin system (RAS) plays essential roles in maintaining peripheral cardiovascular homeostasis, with its potential roles in the brain only being recognized more recently. Angiotensin\u2010I\u2010converting enzyme (ACE) is the main component of the RAS, and it has been implicated in various disorders of the brain. ACE and other RAS components, including the related enzyme ACE2, angiotensin peptides and their respective receptors, can participate in the pathological state, as well as with potential to contribute to neuroprotection and\/or to complement existing treatments for psychiatric illness. In this narrative review, we aimed to identify the main studies describing the functions of the RAS and ACEs in the brain and their association with brain disorders. These include neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, psychiatric illnesses such as schizophrenia, bipolar disorder, and depression. We also discuss the possible association of a functional polymorphism of the<jats:italic>ACE<\/jats:italic>gene with these brain diseases and the relevance of the neuroprotective and anti\u2010inflammatory properties of ACE inhibitors (ACEis) and angiotensin receptor blockers (ARBs). Based on this, we conclude that there is significant potential value to the inclusion of ACEis and\/or ARBs as a novel integrated approach for the treatment of various disorders of the brain, and particularly for psychiatric illness.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15806-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1111\/jnc.15806","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:43:41Z","timestamp":1678689821000},"page":"138-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Angiotensin\u2010converting enzymes as druggable features of psychiatric and neurodegenerative disorders"],"prefix":"10.1111","volume":"166","author":[{"given":"Thays Calista","family":"Santiago","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Parra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o V.","family":"Nani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago M.","family":"Fidalgo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-8828","authenticated-orcid":false,"given":"Nicholas J.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Department of Biotechnology University of Rijeka Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-4923","authenticated-orcid":false,"given":"Mirian A. F.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140816917"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000177156"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010022\u201004007\u2010w"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0167\u20100115(97)00015\u20103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.7.925"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320306"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2019.100034"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866524666170822120258"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201093653\u20103"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.6.733"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361\u20109230(94)90103\u20101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283371355"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.20f13238"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.04.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568007033482661"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.1982.tb07930.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118484"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.03.052"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20103940(03)00026\u20100"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010016\u20102079\u20100"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071708"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866527666200127115059"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344\u2010199219006\u201000011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344\u2010199008000\u201000009"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866524666170728144801"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001775"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.225"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2018.15"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08188"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.73"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.55782\/ane-1996-1103","article-title":"The contribution of AT1 and AT2 angiotensin receptors to its cognitive effects","volume":"1","author":"Braszko J.","year":"1996","journal-title":"Acta Neurobiologiae Experimentalis"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.134.11.aj134111311"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2011.07.013"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac110"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138118"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780618902"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.11.014"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.0005"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000311522"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2020.173063"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076\u20106879(95)48020\u2010x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.586314"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00786"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.04.024"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.1990.tb03810.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.10.001"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00568-3"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.31.4.912"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(86)90411\u20107"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.03.011"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12063"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.02.013"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.87.5.e1"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004\u20100443"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000506"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610120203"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.8.6.544"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605827200"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.20.7741"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.16.4.363"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12799"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010198500301\u201000002"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2021.32"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.09.015"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.181"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.08.018"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.01.044"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1971.221.6.1733"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20102094\u20109\u201038"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00440"},{"key":"e_1_2_9_73_1","first-page":"938","article-title":"Inhibitor analysis of angiotensin I\u2010converting and kinin\u2010degrading activities of bovine lung and testicular angiotensin\u2010converting enzyme","volume":"8","author":"Grinshtein S. V.","year":"1999","journal-title":"Biochemistry"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi035268s"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04756.x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2552"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.2797"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.02.017"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238102.04582.ec"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1003721"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2010.01167.x"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.10.8.4294\u20104302.1990"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.03.087"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03712"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010019\u201000678\u20104"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.837890"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.05.026"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07316"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.10.029"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2021.638519"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517\u2010014\u20102656\u20100"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6254147"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301077"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi202"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0620-0"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5931"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02145"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1781049"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2022.963691"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.02.005"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23112923"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.8.6.540"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41397\u2010018\u20100020\u2010x"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.13304"},{"issue":"3","key":"e_1_2_9_105_1","first-page":"369","article-title":"Association between insertion\/deletion polymorphism in angiotension converting enzyme and susceptibility to schizophrenia","volume":"44","author":"Mazaheri H.","year":"2015","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195911"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu015"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000744\u2010w"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010021\u201000728\u20101"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.09.011"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.11.022"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e3283518524"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012180"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaa050"},{"key":"e_1_2_9_115_1","volume-title":"Animal models in psychiatric disorder studies","author":"Nani J. V.","year":"2019"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2019.1583372"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpab166"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.573677"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2005.03912.x"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010019\u201000632\u20104"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319170013"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)01121\u20106"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001218"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170516"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201079096\u20102"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110668"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.09.024"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.04.014"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1054\/npep.2000.0845"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3545"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp\u20102016\u20100619"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114844"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.11.024"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800911795538147"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.04.002"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010011\u20109754\u20106"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00036.2020"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v11.i9.581"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(00)00259\u20101"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00107"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0090\u201021.2021"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.9.5458"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00498.2016"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201232"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439\u2010004\u20101136\u20104"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.12137"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320313515038"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathophysiology28020020"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20104522(88)90029\u20102"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20101716.1898.tb00272.x"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002615200"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481\u2010016\u20109703\u20108"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108005"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311191200"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.782602"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1395\u201020.2022"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2022.170766"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9293553"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2022.170775"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.01.009"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2021.110348"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2011.579197"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102012\u2010129031"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.12.026"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)67628-3"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2013.11.002"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2008.05723.x"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2016.09.009"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.04.014"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.09.002"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1549\u201007.2007"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.3109\/08039488.2011.555564"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T06:27:56Z","timestamp":1729060076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.15806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,27]]},"references-count":172,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/jnc.15806"],"URL":"https:\/\/doi.org\/10.1111\/jnc.15806","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,27]]},"assertion":[{"value":"2022-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}