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The precise molecular mechanism of neuronal damage during ischemic stroke remains unclear; therefore, the effective treatment of post\u2010ischemic stroke remains a critical challenge. Recently, iron has emerged as a crucial factor in post\u2010reperfusion injuries, participating in cell peroxidation, excitotoxicity, and a distinctive cell death pathway, namely, ferroptosis. Since iron is tightly regulated in the brain and important for brain functions, the imbalance of its metabolism, including its overload and deficiency, has been shown to impact ischemic stroke outcomes. This review summarizes the current understanding of pathological events associated with iron in ischemic stroke and discusses relevant drug development.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15807-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1111\/jnc.15807","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:43:30Z","timestamp":1678689810000},"page":"487-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Iron, ferroptosis, and ischemic stroke"],"prefix":"10.1111","volume":"165","author":[{"given":"Jun","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010zhang","family":"Tuo","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5652-1962","authenticated-orcid":false,"given":"Peng","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.14.7965"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00900"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-191-8_29"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051066"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.04.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23408-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2014.10.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i34.4651"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0212-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.032"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.536714"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42633-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:101:1:73"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160382"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-12-199906150-00003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.049"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-27"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0312-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23817"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3439-14.2015"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2016.15"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1922-y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002921"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1777"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020629818207"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.80"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210796"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01994"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0827"},{"key":"e_1_2_10_32_1","first-page":"CD002087","article-title":"Tirilazad for acute ischaemic stroke","volume":"4","author":"Bath P. 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