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However, impaired lipid metabolism and changes in lipid composition in the brain have been increasingly recognized to play a crucial role in physiological aging, as well as in several neurodegenerative diseases. In the last decades, the role of sexual dimorphism in the vulnerability to develop age\u2010related neurodegeneration has increased. However, further studies are warranted for detailed assessment of how age, sex, and additional non\u2010biological factors may influence the lipid changes in brains. The aim of this work is to address the presence of sex differences in the brain lipid changes that occur along aging, and in the two most common age\u2010related neurodegenerative disorders (Alzheimer's and Parkinson's diseases). We included the studies that assessed lipid\u2010related alterations in the brain of both humans and experimental models. Additionally, we explored the influence of sex on lipid\u2010lowering therapies. We conclude that sex exerts a notable effect on lipid modifications occurring with age and neurodegeneration, and in lipid\u2010reducing interventions. 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