{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:39Z","timestamp":1787015559929,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["39337\/2016\u20100"],"award-info":[{"award-number":["39337\/2016\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["financial code 001"],"award-info":[{"award-number":["financial code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/50891\u20101"],"award-info":[{"award-number":["2014\/50891\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/08287\u20103"],"award-info":[{"award-number":["2019\/08287\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/09207\u20103"],"award-info":[{"award-number":["2019\/09207\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/13112\u20108"],"award-info":[{"award-number":["2019\/13112\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/01107\u20107"],"award-info":[{"award-number":["2020\/01107\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/00527\u20108"],"award-info":[{"award-number":["2022\/00527\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/03297\u20103"],"award-info":[{"award-number":["2022\/03297\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Maternal infections are among the main risk factors for cognitive impairments in the offspring. Zika virus (ZIKV) can be transmitted vertically, causing a set of heterogeneous birth defects, such as microcephaly, ventriculomegaly and corpus callosum dysgenesis. Nuclear distribution element like\u20101 (Ndel1) oligopeptidase controls crucial aspects of cerebral cortex development underlying cortical malformations. Here, we examine Ndel1 activity in an animal model for ZIKV infection, which was associated with deregulated corticogenesis. We observed here a reduction in Ndel1 activity in the forebrain associated with the congenital syndrome induced by ZIKV isolates, in an in utero and postnatal injections of different inoculum doses in mice models. In addition, we observed a strong correlation between Ndel1 activity and brain size of animals infected by ZIKV, suggesting the potential of this measure as a biomarker for microcephaly. More importantly, the increase of interferon (IFN)\u2010beta signaling, which was used to rescue the ZIKV infection outcomes, also recovered Ndel1 activity to levels similar to those of uninfected healthy control mice, but with no influence on Ndel1 activity in uninfected healthy control animals. Taken together, we demonstrate for the first time here an association of corticogenesis impairments determined by ZIKV infection and the modulation of Ndel1 activity. Although further studies are still necessary to clarify the possible role(s) of Ndel1 activity in the molecular mechanism(s) underlying the congenital syndrome induced by ZIKV, we suggest here the potential of monitoring the Ndel1 activity to predict this pathological condition at early stages of embryos or offspring development, during while the currently employed methods are unable to detect impaired corticogenesis leading to microcephaly. Ndel1 activity may also be possibly used to follow up the positive response to the treatment, such as that employing the IFN\u2010beta that is able to rescue the ZIKV\u2010induced brain injury.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15918-fig-0009-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.15918","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T07:25:43Z","timestamp":1690442743000},"page":"763-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response"],"prefix":"10.1111","volume":"166","author":[{"given":"Raissa R.","family":"Christoff","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o V.","family":"Nani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo Brazil"},{"name":"National Institute for Translational Medicine (INCT\u2010TM, CNPq\/FAPESP\/CAPES)  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Lessa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tailene","family":"Rabello","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atila D.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Krenn","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioscience University of Milan\u2010Bicocca  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza M.","family":"Higa","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amilcar","family":"Tanuri","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-1335","authenticated-orcid":false,"given":"Patricia P.","family":"Garcez","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian A. F.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo Brazil"},{"name":"National Institute for Translational Medicine (INCT\u2010TM, CNPq\/FAPESP\/CAPES)  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.190"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010016\u20102395\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.09.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010008\u20100908\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-820267-8.00043-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3791\/54767"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fviro.2022.782906"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.04.029"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.282"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.10.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.02.021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(52)90043-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12551"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag3194"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9030294"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh\u20102022\u2010008784"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12010072"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2022.09.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.01.009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.771557"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6116"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/texcom\/tgaa096"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100664\u20100"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9081216"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051351"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203716666150505225251"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2010.04.006"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500330102"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2243"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.38941"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.826091"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl407"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.773191"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.03.004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010022\u201002460\u20108"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1408.080287"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00394\u201019"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01928"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20130188"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010020\u201002110\u20101"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181ec173d"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1044\/cicsd_33_S_42"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.07.001"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo\u20102021\u2010001235"},{"key":"e_1_2_10_46_1","first-page":"283","volume-title":"Encyclopedia of Behavioral Neuroscience","author":"Nani J. V.","year":"2021"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2021.2023217"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119897562"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201075616\u20102"},{"key":"e_1_2_10_50_1","volume-title":"Animal Models in Medicine and Biology","author":"Nani J. V.","year":"2019"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010042617\u2010053142"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35969"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.11.024"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.10.006"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.17.7812\u20107827.2005"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13112298"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2022.0033"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S113037"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.202100041"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2023.01.014"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.194"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000878"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1811854"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.15212\/zoonoses\u20102021\u20100017"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005363"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4630\u201009.2009"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.659419"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201043303\u20106"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.15918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:08:21Z","timestamp":1692637701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.15918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/jnc.15918"],"URL":"https:\/\/doi.org\/10.1111\/jnc.15918","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]},"assertion":[{"value":"2023-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}