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Dysregulation of these receptors and\/or their associated pathways is strongly implicated in the pathophysiology of epilepsy. To date, hundreds of different GABA<jats:sub>A<\/jats:sub> receptor subunit variants have been associated with epilepsy, making them a prominent cause of genetically linked epilepsy. While identifying these genetic variants is crucial for accurate diagnosis and effective genetic counselling, it does not necessarily lead to improved personalised treatment options. This is because the identification of a variant does not reveal how the function of GABA<jats:sub>A<\/jats:sub> receptors is affected. Genetic variants in GABA<jats:sub>A<\/jats:sub> receptor subunits can cause complex changes to receptor properties resulting in various degrees of gain\u2010of\u2010function, loss\u2010of\u2010function or a combination of both. Understanding how variants affect the function of GABA<jats:sub>A<\/jats:sub> receptors therefore represents an important first step in the ongoing development of precision therapies. Furthermore, it is important to ensure that functional data are produced using methodologies that allow genetic variants to be classified using clinical guidelines such as those developed by the American College of Medical Genetics and Genomics. This article will review the current knowledge in the field and provide recommendations for future functional analysis of genetic GABA<jats:sub>A<\/jats:sub> receptor variants.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15932-fig-0004-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1111\/jnc.15932","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T05:06:17Z","timestamp":1692939977000},"page":"3831-3852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<scp>GABA<sub>A<\/sub><\/scp> receptors in epilepsy: Elucidating phenotypic divergence through functional analysis of genetic variants"],"prefix":"10.1111","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-5991","authenticated-orcid":false,"given":"Nathan L.","family":"Absalom","sequence":"first","affiliation":[{"name":"School of Science University of Western Sydney  Sydney New South Wales Australia"},{"name":"Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3587-0957","authenticated-orcid":false,"given":"Susan X. 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