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We have reviewed here phenotypes and pathological mechanisms of genetic epilepsies caused by variants in Na\n                    <jats:sub>V<\/jats:sub>\n                    \u03b1 and \u03b2 subunits, as well as of some relevant interacting proteins (\n                    <jats:italic>FGF12\/FHF1<\/jats:italic>\n                    , PRRT2, and Ankyrin\u2010G). Notably, variants of all these genes can induce either gain\u2010 or loss\u2010of\u2010function of Na\n                    <jats:sub>V<\/jats:sub>\n                    leading to either neuronal hyperexcitability or hypoexcitability. We present the results of functional studies obtained with different experimental models, highlighting that they should be interpreted considering the features of the experimental system used. These systems are models, but they have allowed us to better understand pathophysiological issues, ameliorate diagnostics, orientate genetic counseling, and select\/develop therapies within a precision medicine framework. These studies have also allowed us to gain insights into the physiological roles of different Na\n                    <jats:sub>V<\/jats:sub>\n                    channels and of the cells that express them. Overall, our review shows the progress that has been made, but also the need for further studies on aspects that have not yet been clarified. Finally, we conclude by highlighting some significant themes of general interest that can be gleaned from the results of the work of the last two decades.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15947-fig-0005-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.15947","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T02:09:50Z","timestamp":1693534190000},"page":"3872-3890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Voltage\u2010gated sodium channels in genetic epilepsy: up and down of excitability"],"prefix":"10.1111","volume":"168","author":[{"given":"Evgeniia","family":"Rusina","sequence":"first","affiliation":[{"name":"University Cote d'Azur  Valbonne\u2010Sophia Antipolis France"},{"name":"CNRS UMR 7275 Institute of Molecular and Cellular Pharmacology (IPMC)  Valbonne\u2010Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Simonti","sequence":"additional","affiliation":[{"name":"University Cote d'Azur  Valbonne\u2010Sophia Antipolis France"},{"name":"CNRS UMR 7275 Institute of Molecular and Cellular Pharmacology (IPMC)  Valbonne\u2010Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Duprat","sequence":"additional","affiliation":[{"name":"University Cote d'Azur  Valbonne\u2010Sophia Antipolis France"},{"name":"CNRS UMR 7275 Institute of Molecular and Cellular Pharmacology (IPMC)  Valbonne\u2010Sophia Antipolis France"},{"name":"Inserm  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