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This orphan receptor is expressed in the retina but its function in the eye is unknown. The earliest studies on GPR75 were conducted in the retina, where the receptor was first identified and cloned and mutations in the receptor were identified as a possible contributor to retinal degenerative disease. Despite these sporadic reports, the function of GPR75 in the retina and in retinal disease has yet to be explored. To assess whether GPR75 has a functional role in the retina, the retina of\n                    <jats:italic>Gpr75<\/jats:italic>\n                    knockout mice was characterized. Knockout mice displayed a mild progressive retinal degeneration, which was accompanied by oxidative stress. The degeneration was because of the loss of both M\u2010cone and S\u2010cone photoreceptor cells. Housing mice under constant dark conditions reduced oxidative stress but did not prevent cone photoreceptor cell loss, indicating that oxidative stress is not a primary cause of the observed retinal degeneration. Studies here demonstrate an important role for GPR75 in maintaining the health of cone photoreceptor cells and that\n                    <jats:italic>Gpr75<\/jats:italic>\n                    knockout mice can be used as a model to study cone photoreceptor cell loss.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15979-fig-0010-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.15979","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:34:07Z","timestamp":1697416447000},"page":"538-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>Gpr75<\/i>\n                    knockout mice display age\u2010dependent cone photoreceptor cell loss"],"prefix":"10.1111","volume":"167","author":[{"given":"Sreelakshmi","family":"Vasudevan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy S.","family":"Samuels","sequence":"additional","affiliation":[{"name":"Research Service VA Northeast Ohio Healthcare System  Cleveland Ohio USA"},{"name":"Department of Ophthalmic Research, Cole Eye Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-9693","authenticated-orcid":false,"given":"Paul S.\u2010H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf8683"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00062-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106257(00)00140\u20105"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00139"},{"issue":"5","key":"e_1_2_10_6_1","first-page":"546","article-title":"Specific binding of peanut lectin to a class of retinal photoreceptor cells. 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