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Furthermore, COVID\u201019 patients exhibit a spectrum of neurological symptoms, indicating that COVID\u201019 can affect the brain in a variety of manners. Many studies, past and recent, suggest a connection between viral infections and an increased risk of neurodegeneration, raising concerns about the neurological effects of COVID\u201019 and the possibility that it may contribute to Alzheimer's disease (AD) onset or worsen already existing AD pathology through inflammatory processes given that both COVID\u201019 and AD share pathological features and risk factors. This leads us to question whether COVID\u201019 is a risk factor for AD and how these two conditions might influence each other. Considering the extensive reach of the COVID\u201019 pandemic and the devastating impact of the ongoing AD pandemic, their combined effects could have significant public health consequences worldwide.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc15985-fig-0002-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.15985","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:05:43Z","timestamp":1697601943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["COVID\u201019 and the impact on Alzheimer's disease pathology"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0809-8992","authenticated-orcid":false,"given":"Susana","family":"Furman","sequence":"first","affiliation":[{"name":"Department of Neurobiology &amp; Behavior, School of Biological Sciences University of California Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-6744","authenticated-orcid":false,"given":"Kim","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Neurobiology &amp; Behavior, School of Biological Sciences University of California Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-0825","authenticated-orcid":false,"given":"Thomas E.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Neurobiology &amp; Behavior, School of Biological Sciences University of California Irvine  Irvine California USA"},{"name":"Department of Molecular Biology &amp; Biochemistry, School of Biological Sciences University of California Irvine  Irvine California USA"},{"name":"Center for Virus Research University of California Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977\u20102694"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12629"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15010114"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102020\u2010000930"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.103"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa183"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010022\u201001754\u20109"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1165"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1934"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2022.114836"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036234\u20104"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0321"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4814\u201007.2008"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.057892"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5801"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803526105"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51067"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577728"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.06.024"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12241"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20101781(93)90029\u2010G"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(20)30600\u20107"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","unstructured":"Chen R. 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