{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:29:35Z","timestamp":1789885775051,"version":"4.0.1"},"reference-count":120,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007460","name":"Arvid Nilssons Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["PhD Grant No: 2018\u2010000009\u201001EXTF\u201000121"],"award-info":[{"award-number":["PhD Grant No: 2018\u2010000009\u201001EXTF\u201000121"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006426","name":"Eva og Henry Fr\u00e6nkels Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["Grant No: 4108\u201000008B"],"award-info":[{"award-number":["Grant No: 4108\u201000008B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009918","name":"Oda og Hans Svenningsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Glutamate recycling between neurons and astrocytes is essential to maintain neurotransmitter homeostasis. Disturbances in glutamate homeostasis, resulting in excitotoxicity and neuronal death, have been described as a potential mechanism in Alzheimer's disease (AD) pathophysiology. However, glutamate neurotransmitter metabolism in different human brain cells, particularly astrocytes, has been poorly investigated at the early stages of AD. We sought to investigate glucose and glutamate metabolism in AD by employing human induced pluripotent stem cell (hiPSC)\u2010derived astrocytes and neurons carrying mutations in the amyloid precursor protein (\n                    <jats:italic>APP<\/jats:italic>\n                    ) or presenilin\u20101 (\n                    <jats:italic>PSEN\u20101<\/jats:italic>\n                    ) gene as found in familial types of AD (fAD). Methods such as live\u2010cell bioenergetics and metabolic mapping using [\n                    <jats:sup>13<\/jats:sup>\n                    C]\u2010enriched substrates were used to examine metabolism in the early stages of AD. Our results revealed greater glycolysis and glucose oxidative metabolism in astrocytes and neurons with\n                    <jats:italic>APP<\/jats:italic>\n                    or\n                    <jats:italic>PSEN\u20101<\/jats:italic>\n                    mutations, accompanied by an elevated glutamate synthesis compared to control WT cells. Astrocytes with\n                    <jats:italic>APP<\/jats:italic>\n                    or\n                    <jats:italic>PSEN\u20101<\/jats:italic>\n                    mutations exhibited reduced expression of the excitatory amino acid transporter 2 (EAAT2), and glutamine uptake increased in mutated neurons, with enhanced glutamate release specifically in neurons with a\n                    <jats:italic>PSEN\u20101<\/jats:italic>\n                    mutation. These results demonstrate a hypermetabolic phenotype in astrocytes with fAD mutations possibly linked to toxic glutamate accumulation. Our findings further identify metabolic imbalances that may occur in the early phases of AD pathophysiology.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16014-fig-0009-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16014","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T09:20:04Z","timestamp":1702027204000},"page":"822-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in\n                    <scp>hiPSC<\/scp>\n                    \u2010derived models of Alzheimer's disease"],"prefix":"10.1111","volume":"168","author":[{"given":"Claudia","family":"Salcedo","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Pozo\u00a0Garcia","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernat","family":"Garc\u00eda\u2010Ad\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-9807","authenticated-orcid":false,"given":"Aishat O.","family":"Ameen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgi","family":"Gegelashvili","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Institute of Chemical Biology, Ilia State University  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4583-8379","authenticated-orcid":false,"given":"Helle S.","family":"Waagepetersen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine K.","family":"Freude","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences Faculty of Health and Medical Sciences, University of Copenhagen  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-1218","authenticated-orcid":false,"given":"Blanca I.","family":"Aldana","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24075"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2857"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010014\u20102919\u2010z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2006.03913.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.803239"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.160059"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00869a048"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00425"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.03.019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022\u20103042.2001.00681.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00902"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2017.10.010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102007\u201012208"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.06.004"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.11.012"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101326\u20102\u201022"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2010.07.021"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23738"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301\u20100082(00)00067\u20108"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.06.030"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2012.02057.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050403"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.1996.67041375.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010003\u20101194\u20101"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x15666170720095240"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.12.019"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101403"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2018.101368"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.08.010"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30028\u20100"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010014\u20100313\u2010y"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010018\u20101075\u2010y"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.2000.00164.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1120086"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00059"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2017.00018"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20100186(03)00022\u20106"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600343"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490330212"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.12.003"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2004.03.007"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010151186"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11051261"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2006.03935.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20100186(03)00039\u20101"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20120007"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20130017"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13439"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2009.12.002"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024232\u20103"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.0720"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00051"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0203\u201011.2011"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.07.001"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05292"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403033300907"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00043"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.09.002"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.08.005"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00561"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:5:2:147"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.04.005"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.11.047"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400512"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.12\u201002\u201000376.1992"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010374947\u20105.00011\u20100"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.1996.66010386.x"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010005\u20101762\u20107"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40336\u2010013\u20100026\u2010y"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0892\u2010345"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010016\u20100092\u20105"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(79)90071\u20104"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5144"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.2741\/e605"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.026"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.2.251"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7861"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301\u20100082(99)00060\u2010x"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.12.027"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010132483"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.736580"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010021\u201003276\u20103"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.104"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.12.011"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24402"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20100186(03)00017\u20102"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24402"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.03.008"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12626"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1334"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.1984.tb12725.x"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903566116"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnene.2013.00001"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.05.015"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520360056039"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.5.469"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00288"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25143"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221669"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170585"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140413"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306832110"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7719"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08797"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.042317"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.2000.0750471.x"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.09.058"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010014\u20101473\u20101"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00869a048"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160763"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010020\u201000376\u20106"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14506.1"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(94)90882\u20106"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3966"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe5640"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.June.29.15"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.01.012"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.16014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:15:51Z","timestamp":1715991351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.16014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,8]]},"references-count":120,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/jnc.16014"],"URL":"https:\/\/doi.org\/10.1111\/jnc.16014","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,8]]},"assertion":[{"value":"2023-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}