{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:54:06Z","timestamp":1791924846662,"version":"4.3.4"},"reference-count":214,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Psilocybin is the main psychoactive compound found in hallucinogenic\/magic mushrooms and can bind to both serotonergic and tropomyosin receptor kinase b (TrkB) receptors. Psilocybin has begun to show efficacy for a range of neuropsychiatric conditions, including treatment\u2010resistant depression and anxiety disorders; however, neurobiological mechanisms are still being elucidated. Clinical research has found that psilocybin can alter functional connectivity patterns in human brains, which is often associated with therapeutic outcomes. However, preclinical research affords the opportunity to assess the potential cellular mechanisms by which psilocybin may exert its therapeutic effects. Preclinical rodent models can also facilitate a more tightly controlled experimental context and minimise placebo effects. Furthermore, where there is a rationale, preclinical researchers can investigate psilocybin administration in neuropsychiatric conditions that have not yet been\u00a0researched clinically. As a result, we have systematically reviewed the knowledge base, identifying 82 preclinical studies which were screened based on specific criteria. This resulted in the exclusion of 44 articles, with 34 articles being included in the main review and another 2 articles included as Supporting Information materials. We found that psilocybin shows promise as a lead candidate molecule for treating a variety of neuropsychiatric conditions, albeit showing the most efficacy for depression. We discuss the experimental findings, and identify possible mechanisms whereby psilocybin could invoke therapeutic changes. Furthermore, we critically evaluate the between\u2010study heterogeneity and possible future research avenues. Our review suggests that preclinical rodent models can provide valid and translatable tools for researching novel psilocybin\u2010induced molecular and cellular mechanisms, and therapeutic outcomes.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16017-fig-0007-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16017","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T09:04:10Z","timestamp":1701248650000},"page":"1687-1720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Psilocybin as a lead candidate molecule in preclinical therapeutic studies of psychiatric disorders: A systematic review"],"prefix":"10.1111","volume":"168","author":[{"given":"James J.","family":"Gattuso","sequence":"first","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health Melbourne Brain Centre University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey","family":"Wilson","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health Melbourne Brain Centre University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Hannan","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health Melbourne Brain Centre University of Melbourne  Parkville Victoria Australia"},{"name":"Faculty of Medicine Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-3971","authenticated-orcid":false,"given":"Thibault","family":"Renoir","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health Melbourne Brain Centre University of Melbourne  Parkville Victoria Australia"},{"name":"Faculty of Medicine Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06123-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01224-X"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.08.003"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S62785"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1074633"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981130)401:4<455::AID-CNE3>3.0.CO;2-6"},{"key":"e_1_2_12_9_1","first-page":"446","article-title":"Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment","volume":"78","author":"Andrews G.","year":"2000","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_12_10_1","article-title":"Marble burying and nestlet shredding as tests of repetitive, compulsive\u2010like behaviors in mice","volume":"82","author":"Angoa\u2010P\u00e9rez M.","year":"2013","journal-title":"JoVE (Journal of Visualized Experiments)"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.10.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.22010073"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59282-y"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713003243"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.123"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-1-9"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-023-06384-w"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.12.004"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.167"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114565144"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.2096"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.06.010"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110600"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2020.1761573"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120959637"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114531666"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01524-1"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00153"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06221-6"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06286-3"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01389-z"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00134"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00718"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-3008-z"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl8615"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116662634"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032994"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4771-x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.118.017160"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.84"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs117"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.103309"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13282-7"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118754710"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00020"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115028"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-013-3579-0"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02039-0"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0823s47"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresprot.2005.09.002"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8721.ep10768783"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1731-10.2010"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1176"},{"key":"e_1_2_12_54_1","first-page":"19","volume-title":"Methods of behavioral analysis in neuroscience","author":"Curzon P.","year":"2009"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114007"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801329105"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2018.08.027"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00637"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01744-z"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1659-20.2020"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01301-9"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109836"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.724606"},{"key":"e_1_2_12_64_1","first-page":"1","article-title":"Does acute stress play a role in the lasting therapeutic effects of psychedelic drugs?","volume":"48","author":"Wit H.","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.075"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.58.1.95"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01706-y"},{"key":"e_1_2_12_68_1","first-page":"10","article-title":"Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity","author":"Du Y.","year":"2023","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2017.00035"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.026120"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.11.004"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02103-9"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001547"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.01.005"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2004.00744.x"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119845793"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyac074"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.046"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy069"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199611000-00004"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.112749"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16325-w"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.008"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00089-X"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117456"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675513"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0457-5"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.116"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079970"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2021.2022254"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyab040"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107933"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.01.017"},{"issue":"1","key":"e_1_2_12_94_1","first-page":"1","article-title":"Serotonin mechanisms in animal models of anxiety","volume":"26","author":"Handley S. L.","year":"1993","journal-title":"Brazilian Journal of Medical and Biological Research= Revista Brasileira de Pesquisas Medicas e Biologicas"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116677852"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022489118"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1089\/psymed.2022.0012"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00493"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.640241"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2022.2044096"},{"key":"e_1_2_12_102_1","volume-title":"LSD: My problem child","author":"Hofmann A.","year":"1980"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.09.003"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(02)00374-3"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000394"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11152384"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15977"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06092-x"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2019.15"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120959614"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114548296"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.05.012"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00123"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010934"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4014-y"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4820-5"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.01.013"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05258-z"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.11.003"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1017\/ipm.2019.39"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.3402\/ejpt.v7.31858"},{"key":"e_1_2_12_122_1","first-page":"4","article-title":"Posttraumatic stress disorder: The burden to the individual and to society","volume":"61","author":"Kessler R. C.","year":"2000","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674221083868"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.01.006"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125320950567"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119857204"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2019.1683260"},{"key":"e_1_2_12_128_1","first-page":"4","article-title":"The burden of depression and anxiety in general medicine","volume":"62","author":"Lecrubier Y.","year":"2001","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-021-00877-y"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1168911"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1556\/2054.2022.00232"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2013.10.004"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111420188"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0324-9"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2020.02.001"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00199-3"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.749068"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8030047"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.90095"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20081251"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0694-z"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh2399"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2015.00078"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2738"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8078"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01316-5"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.04.020"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n1110"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.06.006"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2063-13.2013"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.04.041"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011478"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79328-5"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61462-6"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.113093"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.113865"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.044"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-06020-5"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.10"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00180"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2590"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00045"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708009048"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-023-01613-4"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.21926\/obm.neurobiol.2102102"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00204"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00974"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675512"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00315"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2021.635879"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.11.008"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5480391"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001926"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.07.032"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.06.008"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/35066584"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811221125354"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02456-9"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811221092508"},{"issue":"2","key":"e_1_2_12_181_1","first-page":"1050","article-title":"Neurochemical and behavioral evidence that quipazine\u2010ketanserin discrimination is mediated by serotonin2A receptor","volume":"275","author":"Smith R. L.","year":"1995","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110382466"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2016-0007"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22562"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01846-9"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.03.003"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-023-01545-z"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14720"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800212-4.00073-X"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20047"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1134454"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01923013"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2020.00034"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf0435"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01603-4"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.05.029"},{"key":"e_1_2_12_197_1","article-title":"With great power comes great vulnerability: An ethical analysis of psychedelics' therapeutic mechanisms proposed by the REBUS hypothesis","author":"Villiger D.","year":"2023","journal-title":"Journal of Medical Ethics"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01031.x"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(96)00246-1"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199812010-00024"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00108-0"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.12.019"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022167817709585"},{"key":"e_1_2_12_204_1","first-page":"36","article-title":"Htr2a gene and 5\u2010HT2A receptor expression in the cerebral cortex studied using genetically modified mice","volume":"4","author":"Weber E. T.","year":"2010","journal-title":"Frontiers in Neuroscience"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2016.08.002"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106223"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.107998"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-021-02283-y"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126713"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00194"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012941"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.57"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-022-00933-7"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28062624"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.11.026"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.16017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T09:35:52Z","timestamp":1737452152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.16017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,29]]},"references-count":214,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jnc.16017"],"URL":"https:\/\/doi.org\/10.1111\/jnc.16017","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.16017\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16017\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16017\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16017\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16017\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16017\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16017\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16017\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16017\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,29]]},"assertion":[{"value":"2023-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}