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Damage to oligodendrocytes, which are the key cells involved in WMI pathogenesis, can directly lead to myelin abnormalities.\n                    <jats:sc>L<\/jats:sc>\n                    \u2010ascorbyl\u20102\u2010phosphate (AS\u20102P) is a stable form of vitamin C. This study aimed to explore the protective effects of AS\u20102P against chronic hypoxia\u2010induced WMI, and elucidate the underlying mechanisms. An in\u00a0vivo chronic hypoxia model and in\u00a0vitro oxygen\u2013glucose deprivation (OGD) model were established to explore the effects of AS\u20102P on WMI using immunofluorescence, immunohistochemistry, western blotting, real\u2010time quantitative polymerase chain reaction, Morris water maze test, novel object recognition test, beaming\u2010walking test, electron microscopy, and flow cytometry. The results showed that AS\u20102P resulted in the increased expression of MBP, Olig2, PDGFR\u03b1 and CC1, improved thickness and density of the myelin sheath, and reduced TNF\u2010\u03b1 expression and microglial cell infiltration to alleviate inflammation in the brain after chronic hypoxia. Moreover, AS\u20102P improved the memory, learning and motor abilities of the mice with WMI. These protective effects of AS\u20102P may involve the upregulation of protein arginine methyltransferase 5 (PRMT5) and downregulation of P53 and NF\u2010\u03baB. In conclusion, our study demonstrated that AS\u20102P attenuated chronic hypoxia\u2010induced WMI in\u00a0vivo and OGD\u2010induced oligodendrocyte injury in\u00a0vitro possibly by regulating the PRMT5\/P53\/NF\u2010\u03baB pathway, suggesting that AS\u20102P may be a potential therapeutic option for WMI.\n                  <\/jats:p>","DOI":"10.1111\/jnc.16038","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T05:19:31Z","timestamp":1704259171000},"page":"142-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>L<\/scp>\n                    \u2010ascorbyl\u20102\u2010phosphate alleviates white matter injury caused by chronic hypoxia through the\n                    <scp>PRMT5<\/scp>\n                    \/\n                    <scp>P53<\/scp>\n                    \/\n                    <scp>NF\u2010\u03baB<\/scp>\n                    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