{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:45Z","timestamp":1772160705845,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042021kf0042"],"award-info":[{"award-number":["2042021kf0042"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042023kf1064"],"award-info":[{"award-number":["2042023kf1064"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M712473"],"award-info":[{"award-number":["2022M712473"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Controversial findings regarding the association between serum cholesterol levels and Alzheimer's disease (AD) have been identified through observational studies. The genetic basis shared by both factors and the causality between them remain largely unknown. The objective of this study is to examine the causal impact of maternal history of AD on changes in serum cholesterol levels in adult offspring. By retrieving genetic variants from summary statistics of large\u2010scale genome\u2010wide association study of maternal history of AD (European\u2010based:\n                    <jats:italic>N<\/jats:italic>\n                    case\u2009=\u200927\u2009696,\n                    <jats:italic>N<\/jats:italic>\n                    control\u2009=\u2009260\u2009980). The causal association between genetically predicted maternal history of AD and changes in serum cholesterol levels in adult offspring was examined using the two\u2010sample Mendelian randomization (MR) method. Causal impact estimates were calculated using single\u2010nucleotide polymorphisms in both univariable MR (UMR) and multivariable MR (MVMR) analyses. Additionally, other approaches, such as Cochran's\n                    <jats:italic>Q<\/jats:italic>\n                    test and leave\u2010one\u2010out variant analysis, were employed to correct for potential biases. The results of UMR presented that genetically predicted maternal history of AD was positively associated with hypercholesterolemia (OR\u2009=\u20091.014; 95% CI: 1.009\u20131.018;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), total cholesterol (OR\u2009=\u20091.29; 95% CI: 1.134\u20131.466;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and low\u2010density lipoprotein (OR\u2009=\u20091.525; 95% CI: 1.272\u20131.828;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) among adult offspring. Genetic predisposition for maternal history of AD to be negatively associated with high\u2010density lipoprotein (OR\u2009=\u20090.889; 95% CI: 0.861\u20130.917;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The MVMR analysis remained robust and significant after adjusting for diabetes and obesity in offspring. Sufficient evidence was provided in this study to support the putative causal impact of maternal history of AD on the change of serum cholesterol profile in adult offspring. In clinical practice, priority should be given to the detection and monitoring of cholesterol levels in individuals with a maternal history of AD, particularly in the early stages.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16056-fig-0003-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16056","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:31:23Z","timestamp":1707276683000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal history of Alzheimer's disease predisposes to altered serum cholesterol levels in adult offspring"],"prefix":"10.1111","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-2235","authenticated-orcid":false,"given":"Yuehui","family":"Liang","sequence":"first","affiliation":[{"name":"School of Public Health Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3154-6909","authenticated-orcid":false,"given":"Ming\u2010Gang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Wuhan Mental Health Centre  Wuhan China"},{"name":"Department of Psychiatry Wuhan Hospital for Psychotherapy  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghong","family":"Jian","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatology Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Wuhan University  Wuhan China"},{"name":"Julius Global Health, The Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health Wuhan University  Wuhan 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