{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:35Z","timestamp":1772160695294,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    For CNS lymphomas (CNSL), there is a high need for minimally invasive and easily obtainable diagnostic markers. Intrathecal IgM synthesis can easily be determined in routine CSF diagnostics. The aim of this study was to systematically investigate the diagnostic potential of intrathecal IgM synthesis in primary and secondary CNSL (PCNSL and SCNSL). In this retrospective study, patients with a biopsy\u2010proven diagnosis of PCNSL or SCNSL were compared with patients with other neurological diseases in whom CNSL was initially the primary radiological differential diagnosis based on MRI. Sensitivity and specificity of intrathecal IgM synthesis were calculated using receiver operating characteristic curves. Seventy patients with CNSL were included (49 PCNSL and 21 SCNSL) and compared to 70 control patients. The sensitivity and specificity for the diagnosis of CNSL were 49% and 87%, respectively, for the entire patient population and 66% and 91% after selection for cases with tumor access to the CSF system and isolated intrathecal IgM synthesis. In cases with MRI\u2010based radiological suspicion of CNSL, intrathecal IgM synthesis has good specificity but limited sensitivity. Because of its low\u2010threshold availability, analysis of intrathecal IgM synthesis has the potential to lead to higher diagnostic accuracy, especially in resource\u2010limited settings, and deserves further study.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16069-fig-0006-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16069","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:34:41Z","timestamp":1707438881000},"page":"1157-1167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrathecal\n                    <scp>IgM<\/scp>\n                    synthesis as a diagnostic marker in patients with suspected\n                    <scp>CNS<\/scp>\n                    lymphoma"],"prefix":"10.1111","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-7234","authenticated-orcid":false,"given":"Raphael","family":"Reinecke","sequence":"first","affiliation":[{"name":"Dr. Senckenberg Institute of Neurooncology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Department of Neurology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"University Cancer Center (UCT), Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kolja","family":"Jahnke","sequence":"additional","affiliation":[{"name":"Department of Neurology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Foltyn\u2010Dumitru","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Neurooncology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Department of Neuroradiology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Lachner","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-8548","authenticated-orcid":false,"given":"Moritz","family":"Armbrust","sequence":"additional","affiliation":[{"name":"Neurological Institute (Edinger Institute) Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina J.","family":"Weber","sequence":"additional","affiliation":[{"name":"University Cancer Center (UCT), Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Neurological Institute (Edinger Institute) Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), partner site Frankfurt\/Mainz, a partnership between DKFZ and University Hospital Frankfurt  Frankfurt am Main Germany"},{"name":"Frankfurt Cancer Institute (FCI), Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6626-9211","authenticated-orcid":false,"given":"Pia S.","family":"Zeiner","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Neurooncology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Department of Neurology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"University Cancer Center (UCT), Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), partner site Frankfurt\/Mainz, a partnership between DKFZ and University Hospital Frankfurt  Frankfurt am Main Germany"},{"name":"Frankfurt Cancer Institute (FCI), Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Czabanka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Brunnberg","sequence":"additional","affiliation":[{"name":"University Cancer Center (UCT), Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Department of Medicine, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-1091","authenticated-orcid":false,"given":"Sylvia","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim\u00a0P.","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Department of Neurology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"University Cancer Center (UCT), Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), partner site Frankfurt\/Mainz, a partnership between DKFZ and University Hospital Frankfurt  Frankfurt am Main Germany"},{"name":"Frankfurt Cancer Institute (FCI), Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-6290","authenticated-orcid":false,"given":"Michael W.","family":"Ronellenfitsch","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Neurooncology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"Department of Neurology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"University Cancer Center (UCT), Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), partner site Frankfurt\/Mainz, a partnership between DKFZ and University Hospital Frankfurt  Frankfurt am Main Germany"},{"name":"Frankfurt Cancer Institute (FCI), Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0908-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112665"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1161-z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.05.015"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093903"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12980"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1987.00520210017012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030403"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00439-0"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17357"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111444"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15661"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4867"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.09.014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.25259\/JCIS_135_2021"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4450"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.016113"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.03.080"},{"key":"e_1_2_11_20_1","first-page":"7798","article-title":"Corticosteroid pre\u2010treated primary CNS lymphoma: A detailed analysis of stereotactic biopsy findings and consideration of interobserver variability","volume":"8","author":"\u00d6nder E.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac202"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-1-49"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09315-8"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u2010510x(94)90298\u20104"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00501-3"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0692-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-476333"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1622-z"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01516.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.606"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S255482"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2014.085"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.9.1663"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006254518848"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb05053.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15133"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.16069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T13:51:34Z","timestamp":1716990694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.16069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,8]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jnc.16069"],"URL":"https:\/\/doi.org\/10.1111\/jnc.16069","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.16069\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16069\/v1\/review1","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,8]]},"assertion":[{"value":"2023-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}