{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:12:09Z","timestamp":1790359929613,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG078796"],"award-info":[{"award-number":["R01AG078796"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) affects one in eight individuals over 65 and poses an immense societal challenge. AD pathology is characterized by the formation of beta\u2010amyloid plaques and Tau tangles in the brain. While some disease\u2010modifying treatments targeting beta\u2010amyloid are emerging, the exact chain of events underlying the pathogenesis of this disease remains unclear. Brain lipids have long been implicated in AD pathology, though their role in AD pathogenesis remains not fully resolved. Significant advancements in mass spectrometry imaging (MSI) allow to detail spatial lipid regulations in biological tissues at the low um scale. In this issue, Huang et\u00a0al. resolve spatial lipid patterns in human AD brain and genetic mouse models using desorption electrospray ionization (DESI)\u2010based MSI integrated with other spatial techniques such as imaging mass cytometry of correlative protein signatures. Those spatial multiomics experiments identify plaque\u2010associated lipid regulations that are dependent on progressing plaque pathology in both mouse models and the human brain. Of those lipid species, particularly pro\u2010inflammatory lysophospholipids have been implicated in AD pathology through their interaction with both aggregating A\u03b2 and microglial activation through lipid sensing surface receptors. Together, this study provides further insight into how brain lipid homeostasis is linked to progressing AD pathology, and thereby highlights the potential of MSI\u2010based spatial lipidomics as an emerging spatial biology technology for biomedical research.<\/jats:p>","DOI":"10.1111\/jnc.16079","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T09:15:25Z","timestamp":1708334125000},"page":"1175-1178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lipid imaging of Alzheimer's disease pathology"],"prefix":"10.1111","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-198X","authenticated-orcid":false,"given":"J\u00f6rg","family":"Hanrieder","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Sahlgrenska Academy, University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Science for Life Laboratory (SciLife) University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Neurodegenerative Disease Queen Square Institute of Neurology, University College London  London 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