{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:13:55Z","timestamp":1788365635287,"version":"build-2803163510"},"reference-count":370,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010523","name":"Centre for Addiction and Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010523","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2022016F"],"award-info":[{"award-number":["A2022016F"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG069130"],"award-info":[{"award-number":["AG069130"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG079774"],"award-info":[{"award-number":["AG079774"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Brain\u2010derived extracellular vesicles (EVs) serve a prominent role in maintaining homeostasis and contributing to pathology in health and disease. This review establishes a crucial link between physiological processes leading to EV biogenesis and their impacts on disease. EVs are involved in the clearance and transport of proteins and nucleic acids, responding to changes in cellular processes associated with neurodegeneration, including autophagic disruption, organellar dysfunction, aging, and other cell stresses. In neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, etc.), EVs contribute to the spread of pathological proteins like amyloid \u03b2, tau, \u0251\u2010synuclein, prions, and TDP\u201043, exacerbating neurodegeneration and accelerating disease progression. Despite evidence for both neuropathological and neuroprotective effects of EVs, the mechanistic switch between their physiological and pathological functions remains elusive, warranting further research into their involvement in neurodegenerative disease. Moreover, owing to their innate ability to traverse the blood\u2013brain barrier and their ubiquitous nature, EVs emerge as promising candidates for novel diagnostic and therapeutic strategies. The review uniquely positions itself at the intersection of EV cell biology, neurophysiology, and neuropathology, offering insights into the diverse biological roles of EVs in health and disease.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16108-fig-0005-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16108","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T02:00:51Z","timestamp":1713837651000},"page":"2391-2422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology"],"prefix":"10.1111","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1874-7950","authenticated-orcid":false,"given":"Stephanie","family":"Tam","sequence":"first","affiliation":[{"name":"Brain Health Imaging Centre Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy","family":"Wear","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Morrone","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre Centre for Addiction and Mental Health  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Haung","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100642"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040571"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2019.11.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000713"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"23","article-title":"Different types of cellular stress affect the proteome composition of small extracellular vesicles: A mini review","volume":"7","author":"Abramowicz A.","year":"2019","journal-title":"PRO"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311769"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.7b00585"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129598"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/BC20080025"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-6-47"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.489"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00791-x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.093"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.06.017"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.13640"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4132"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12834"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30766"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160371"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.787356"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.035"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.04.011"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124407"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1438807"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14020325"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200861"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103441"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.02.013"},{"issue":"8","key":"e_1_2_11_30_1","first-page":"272","article-title":"Transmissible endosomal intoxication: A balance between exosomes and lysosomes at the basis of intercellular amyloid propagation","volume":"8","author":"B\u00e9cot A.","year":"2020","journal-title":"Biomedicine"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00124"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.08.001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5847"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.12.009"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01153-8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.11.032"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013201"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12208"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031365"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57497-7"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0403-9"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84268-9"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr500854x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2016.12.005"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.08.005"},{"issue":"4","key":"e_1_2_11_47_1","first-page":"1","article-title":"The roles of extracellular vesicles in the immune system","volume":"23","author":"Buzas E. I.","year":"2022","journal-title":"Nature Reviews. Immunology"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab225"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272703"},{"key":"e_1_2_11_50_1","article-title":"The ubiquitination machinery of the ubiquitin system","volume":"12","author":"Callis J.","year":"2014","journal-title":"The Arabidopsis Book\/American Society of Plant Biologists"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.04.048"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.20.3.473"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030516"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.05.021"},{"issue":"2","key":"e_1_2_11_55_1","first-page":"457","article-title":"Membrane\u2010associated Hsp72 from tumor\u2010derived exosomes mediates STAT3\u2010dependent immunosuppressive function of mouse and human myeloid\u2010derived suppressor cells","volume":"120","author":"Chalmin F.","year":"2010","journal-title":"The Journal of Clinical Investigatio"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-010-0233-9"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.250241"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-016-0458-3"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2473-5"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001372"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25884"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197016"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.03.021"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1066"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031022"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.10.022"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0671"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.24.7151"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213753"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.734720"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70142-4"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.06.004"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24158"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09710-3"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.08.002"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12295"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4144"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00719-1"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe5085"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-42"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.031"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v1i0.18396"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0546-4"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2095788"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10050993"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0216"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2016.1251000"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aai7696"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4680"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.02.012"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0189-0"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0254-2"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070727"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14301-3"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.12.023"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1449com"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015353"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5699-09.2010"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030436"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-3-10"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101202"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2007.00677.x"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800049-JLR200"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13514"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0821-4"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12188"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201504057"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00574"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308413101"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.06.008"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.01.017"},{"key":"e_1_2_11_112_1","volume-title":"Lactic Acidosis. StatPearls","author":"Foucher C. D.","year":"2022"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.04.30.537820"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101034"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001604"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000621"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101874"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315506"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0816-2"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12050442"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-020-08607-1"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2017.10.005"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14725-x"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.3.864"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1831413100"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09363-4"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.585703"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.12.011"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1089\/neur.2022.0058"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6158"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202101055"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0165-0"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.684258"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03991-3"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa090"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0261-9"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S291138"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-018-0622-5"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010410"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13158"},{"key":"e_1_2_11_141_1","volume-title":"Lewy body dementia","author":"Haider A.","year":"2022"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-0506"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.03.033"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(09)00411-5"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01382-x"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.763"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.97.2.329"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00194"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02757-8"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.425"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)82050-X"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0039-x"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2309-8"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.01.023"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30751-8"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01969-17"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww237"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.77.061606.161055"},{"issue":"15","key":"e_1_2_11_159_1","first-page":"2394","article-title":"Evaluating different routes of extracellular vesicle administration for cranial therapies","volume":"6","author":"Ioannides P.","year":"2020","journal-title":"Journal of Cancer Metastasis and Treatment"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125019"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.01.002"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21681"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020170"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00722-4"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2462"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2066-6"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1972.33"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-022-03621-0"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0774-8"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522297113"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-022-01387-1"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03701-1"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-421"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12121171"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.06.022"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04723"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu099"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00798-4"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.15586\/codonpublications.parkinsonsdisease.2018.ch1"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7110215"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.03.017"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1408-1"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2012.08.008"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13283"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0692-05.2005"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.09.069"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.03.034"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071728"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.05.068"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c00929"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2015.11.009"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151434"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05292"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700611"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.08.037"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30607"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-021-01040-3"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.667369"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136822"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106098"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12681.1"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005860"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0821-y"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7658921"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13541"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02912068"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0991-5"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170913164738"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12070957"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-67171-6_16"},{"issue":"1","key":"e_1_2_11_212_1","article-title":"Extracellular vesicles in amyotrophic lateral sclerosis","volume":"13","author":"McCluskey G.","year":"2022","journal-title":"Life (Basel)."},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201708092"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2004.6.3\/imckeith"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201603105"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01310"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11534-w"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1748758"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.10.078"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.569818"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1395992"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa616"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.161"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04397"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26300"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.53"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00033"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3823"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0223-5"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-26666-4_9"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10030139"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12403-6"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152213"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.04.013"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.735001"},{"key":"e_1_2_11_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2020.01.001"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02444-1"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0445-5"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.024"},{"key":"e_1_2_11_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.101020"},{"key":"e_1_2_11_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.06.007"},{"key":"e_1_2_11_245_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.22.1.123"},{"key":"e_1_2_11_246_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.584791"},{"key":"e_1_2_11_247_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0306-8"},{"key":"e_1_2_11_248_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12398"},{"key":"e_1_2_11_249_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.3.942"},{"key":"e_1_2_11_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22068-4"},{"key":"e_1_2_11_251_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5371"},{"key":"e_1_2_11_252_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00526"},{"issue":"1","key":"e_1_2_11_253_1","article-title":"IKK\u03b2 activation promotes amphisome formation and extracellular vesicle secretion in tumor cells. Biochimica et Biophysica Acta (BBA)\u2014molecular","volume":"1868","author":"Peng X.","year":"2021","journal-title":"Cell Research"},{"key":"e_1_2_11_254_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.691648"},{"key":"e_1_2_11_255_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001166"},{"key":"e_1_2_11_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/jex2.79"},{"key":"e_1_2_11_257_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-19-551"},{"key":"e_1_2_11_258_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.601740"},{"key":"e_1_2_11_259_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_11_260_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02254-3"},{"key":"e_1_2_11_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.04.016"},{"key":"e_1_2_11_262_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2019.1650371"},{"key":"e_1_2_11_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.06.013"},{"key":"e_1_2_11_264_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00025"},{"key":"e_1_2_11_265_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14371-3"},{"key":"e_1_2_11_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.09.066"},{"key":"e_1_2_11_267_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.580030"},{"key":"e_1_2_11_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(03)00080-2"},{"key":"e_1_2_11_269_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603838103"},{"key":"e_1_2_11_270_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-022-00359-3"},{"key":"e_1_2_11_271_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.1161"},{"key":"e_1_2_11_272_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201211138"},{"key":"e_1_2_11_273_1","first-page":"5","article-title":"Antisense oligonucleotides extend survival of prion\u2010infected mice. JCI","volume":"4","author":"Raymond G. J.","year":"2019","journal-title":"Insight"},{"key":"e_1_2_11_274_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10050384"},{"key":"e_1_2_11_275_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202000660"},{"key":"e_1_2_11_276_1","doi-asserted-by":"publisher","DOI":"10.1159\/000212572"},{"key":"e_1_2_11_277_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020267"},{"key":"e_1_2_11_278_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5173732"},{"key":"e_1_2_11_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.02.016"},{"key":"e_1_2_11_280_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa376"},{"key":"e_1_2_11_281_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.589564"},{"key":"e_1_2_11_282_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00540"},{"key":"e_1_2_11_283_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040851"},{"key":"e_1_2_11_284_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010350"},{"key":"e_1_2_11_285_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.11.8821-8831.1997"},{"key":"e_1_2_11_286_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4479"},{"key":"e_1_2_11_287_1","doi-asserted-by":"publisher","DOI":"10.1096\/fba.2021-00035"},{"key":"e_1_2_11_288_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317492"},{"key":"e_1_2_11_289_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1678579"},{"key":"e_1_2_11_290_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.57701"},{"key":"e_1_2_11_291_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15433"},{"issue":"7","key":"e_1_2_11_292_1","first-page":"572","article-title":"Aging, basal metabolic rate, and nutrition","volume":"30","author":"Shimokata H.","year":"1993","journal-title":"Nihon Ronen Igakkai Zasshi Japanese Journal of Geriatrics."},{"key":"e_1_2_11_293_1","volume-title":"StatPearls","author":"Sitammagari K. K.","year":"2022"},{"key":"e_1_2_11_294_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0448-9"},{"key":"e_1_2_11_295_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403186"},{"key":"e_1_2_11_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.09.021"},{"key":"e_1_2_11_297_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202110151"},{"key":"e_1_2_11_298_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09720-x"},{"key":"e_1_2_11_299_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00095"},{"key":"e_1_2_11_300_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.11.057"},{"key":"e_1_2_11_301_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00344"},{"key":"e_1_2_11_302_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00487"},{"key":"e_1_2_11_303_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12712"},{"key":"e_1_2_11_304_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg6666"},{"key":"e_1_2_11_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.03.030"},{"key":"e_1_2_11_306_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv346"},{"key":"e_1_2_11_307_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0066"},{"key":"e_1_2_11_308_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.105"},{"key":"e_1_2_11_309_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3807476"},{"key":"e_1_2_11_310_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-323520"},{"key":"e_1_2_11_311_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15033403"},{"key":"e_1_2_11_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.03.016"},{"key":"e_1_2_11_313_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-021-01849-z"},{"key":"e_1_2_11_314_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17-0185"},{"key":"e_1_2_11_315_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-210311"},{"key":"e_1_2_11_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.02.057"},{"key":"e_1_2_11_317_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7309"},{"key":"e_1_2_11_318_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_2_11_319_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.68"},{"key":"e_1_2_11_320_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.083"},{"key":"e_1_2_11_321_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S200490"},{"key":"e_1_2_11_322_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101266"},{"key":"e_1_2_11_323_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601910383011"},{"key":"e_1_2_11_324_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040991"},{"key":"e_1_2_11_325_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101520"},{"key":"e_1_2_11_326_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00001.2003"},{"key":"e_1_2_11_327_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.120"},{"key":"e_1_2_11_328_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.02.006"},{"key":"e_1_2_11_329_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1596"},{"key":"e_1_2_11_330_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1596668"},{"key":"e_1_2_11_331_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31181-y"},{"key":"e_1_2_11_332_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01245-z"},{"key":"e_1_2_11_333_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1945-8"},{"key":"e_1_2_11_334_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13588"},{"key":"e_1_2_11_335_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.13"},{"key":"e_1_2_11_336_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00244-22"},{"key":"e_1_2_11_337_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6476-10.2011"},{"key":"e_1_2_11_338_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1987673"},{"key":"e_1_2_11_339_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0143-y"},{"key":"e_1_2_11_340_1","doi-asserted-by":"crossref","DOI":"10.1177\/09636897221083549","article-title":"The endoplasmic reticulum\u2010stressed head and neck squamous cell carcinoma cells induced Exosomal miR\u2010424\u20105p inhibits angiogenesis and migration of Humanumbilical vein endothelial cells through LAMC1\u2010mediated Wnt\/\u03b2\u2010catenin signaling pathway","volume":"31","author":"Wang Z.","year":"2022","journal-title":"Cell Transplantation"},{"key":"e_1_2_11_341_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00488-7"},{"key":"e_1_2_11_342_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12484"},{"key":"e_1_2_11_343_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav8521"},{"key":"e_1_2_11_344_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22519"},{"key":"e_1_2_11_345_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12365"},{"key":"e_1_2_11_346_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.145.1.20"},{"key":"e_1_2_11_347_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006682"},{"key":"e_1_2_11_348_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08712-9"},{"key":"e_1_2_11_349_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089534"},{"key":"e_1_2_11_350_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.955175"},{"key":"e_1_2_11_351_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343491"},{"key":"e_1_2_11_352_1","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27066"},{"key":"e_1_2_11_353_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00024-18"},{"key":"e_1_2_11_354_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1204-7"},{"key":"e_1_2_11_355_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15367"},{"key":"e_1_2_11_356_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101237"},{"key":"e_1_2_11_357_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.955419"},{"key":"e_1_2_11_358_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax8849"},{"key":"e_1_2_11_359_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00810-2"},{"key":"e_1_2_11_360_1","doi-asserted-by":"publisher","DOI":"10.1093\/biosci\/biv084"},{"key":"e_1_2_11_361_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-6-274"},{"key":"e_1_2_11_362_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqz028"},{"key":"e_1_2_11_363_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00178.2017"},{"key":"e_1_2_11_364_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.11.JNS14770"},{"key":"e_1_2_11_365_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.03.006"},{"key":"e_1_2_11_366_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.574007"},{"key":"e_1_2_11_367_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-017-9711-x"},{"issue":"1","key":"e_1_2_11_368_1","first-page":"80","article-title":"Isolation and analysis methods of extracellular vesicles (EVs)","volume":"2","author":"Zhao Z.","year":"2021","journal-title":"Extracellular Vesicles and Circulating Nucleic Acids"},{"issue":"3","key":"e_1_2_11_369_1","first-page":"1170","article-title":"Extracellular vesicles degradation pathway based autophagy lysosome pathway","volume":"11","author":"Zheng J.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_370_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201901231"},{"key":"e_1_2_11_371_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801313"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.16108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T09:30:07Z","timestamp":1737451807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.16108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":370,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jnc.16108"],"URL":"https:\/\/doi.org\/10.1111\/jnc.16108","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.16108\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16108\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16108\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16108\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16108\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16108\/v2\/response1","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2024-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}