{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:38:22Z","timestamp":1792431502528,"version":"4.5.0"},"reference-count":142,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009104","name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila","doi-asserted-by":"publisher","award":["FAR 2023_DSV"],"award-info":[{"award-number":["FAR 2023_DSV"]}],"id":[{"id":"10.13039\/100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009104","name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila","doi-asserted-by":"publisher","award":["FAR2023_Ricerca diffusa_DBMN"],"award-info":[{"award-number":["FAR2023_Ricerca diffusa_DBMN"]}],"id":[{"id":"10.13039\/100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The endocannabinoid system (ECS) plays an important role in neuroprotection, neuroplasticity, energy balance, modulation of stress, and inflammatory responses, acting as a critical link between the brain and the body's peripheral regions, while also offering promising potential for novel therapeutic strategies. Unfortunately, in humans, pharmacological inhibitors of different ECS enzymes have led to mixed results in both preclinical and clinical studies. As the ECS has been highly conserved throughout the eukaryotic lineage, the use of invertebrate model organisms like the pond snail\n                    <jats:italic>Lymnaea stagnalis<\/jats:italic>\n                    may provide a flexible tool to unravel unexplored functions of the ECS at the cellular, synaptic, and behavioral levels. In this study, starting from the available genome and transcriptome of\n                    <jats:italic>L. stagnalis<\/jats:italic>\n                    , we first identified putative transcripts of all ECS enzymes containing an open reading frame. Each predicted protein possessed a high degree of sequence conservation to known orthologues of other invertebrate and vertebrate organisms. Sequences were confirmed by qualitative PCR and sequencing. Then, we investigated the transcriptional effects induced by different stress conditions (i.e., bacterial LPS injection, predator scent, food deprivation, and acute heat shock) on the expression levels of the enzymes of the ECS in\n                    <jats:italic>Lymnaea<\/jats:italic>\n                    's central ring ganglia. Our results suggest that in\n                    <jats:italic>Lymnaea<\/jats:italic>\n                    as in rodents, the ECS is involved in mediating inflammatory and anxiety\u2010like responses, promoting energy balance, and responding to acute stressors. To our knowledge, this study offers the most comprehensive analysis so far of the ECS in an invertebrate model organism.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16147-fig-0006-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.16147","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T22:39:02Z","timestamp":1719095942000},"page":"2848-2867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Different stressors uniquely affect the expression of endocannabinoid\u2010metabolizing enzymes in the central ring ganglia of\n                    <i>Lymnaea stagnalis<\/i>"],"prefix":"10.1111","volume":"168","author":[{"given":"Veronica","family":"Rivi","sequence":"first","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Rigillo","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Batabyal","sequence":"additional","affiliation":[{"name":"Department of Physical and Natural Sciences FLAME University  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Lukowiak","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pani","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Department of Psychiatry and Behavioral Sciences University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Tascedda","sequence":"additional","affiliation":[{"name":"Centre of Neuroscience and Neurotechnology University of Modena and Reggio Emilia  Modena Italy"},{"name":"Department of Life Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"CIB, Consorzio Interuniversitario Biotecnologie  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-9525","authenticated-orcid":false,"given":"Cristina","family":"Benatti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Centre of Neuroscience and Neurotechnology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M. C.","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Centre of Neuroscience and Neurotechnology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-022-00436-x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2021-1926"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.603979"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.03.035"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2017.12.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42826-022-00116-5"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209788168029"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2017.17025"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2022.05.013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2021.113509"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.242761"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2023.109805"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.05.017"},{"key":"e_1_2_11_16_1","first-page":"251","article-title":"Transcriptional effect of serotonin in the ganglia of Lymnaea stagnalis","volume":"14","author":"Benatti C.","year":"2017","journal-title":"Invertebrate Survival Journal"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.02.023"},{"key":"e_1_2_11_18_1","first-page":"129","article-title":"Redefining operant conditioning of escape behavior in Lymnaea stagnalis","volume":"17","author":"Benatti C.","year":"2020","journal-title":"Invertebrate Survival Journal"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.01.017"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2760(97)00009-X"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7458"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00479"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042103"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19652-0"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.06.007"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2427.2007.01843.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.09.006"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00749-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1470919"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.204"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13876"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00145-3"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2007.04.025"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0394"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2010.00181"},{"key":"e_1_2_11_36_1","first-page":"1","article-title":"The endocannabinoid system in Caenorhabditis elegans","volume":"184","author":"Estrada\u2010Valencia R.","year":"2023","journal-title":"Reviews of Physiology, Biochemistry and Pharmacology"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.05.026"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-451"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.242513"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56962"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab014"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-016-1086-z"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420889.2015.1040954"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24925-8"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.033"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.032"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv091"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110116"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(16)30039-5"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01251-0"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.02.016"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113007"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.20.9574"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914661107"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4283-10.2010"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2017.08.006"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.048256"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/24750263.2017.1363303"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.120329"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422414000080"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.212886"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.245566"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.243840"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150420"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704767"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1086\/BBLv220n1p71"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.03.003"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.10.006"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601832103"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3848-07.2008"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.02.006"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15000"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.014886"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.089441"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4036"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.04.005"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14121316"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03103.x"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.11.004"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00109-D"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2023.106295"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.07.005"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.166"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.10.025"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0679-12.2013"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.164806"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306642200"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.010173"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5132-07.2008"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.032110"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)00049-6"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.09.009"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-20"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100293"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315228"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-017-0924-x"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-021-01522-1"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2023.114137"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2021.103170"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-023-01649-3"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1086\/720948"},{"key":"e_1_2_11_102_1","first-page":"1573","volume-title":"Aspirin reverts lipopolysaccharide\u2010induced learning and memory impairment: First evidence from an invertebrate model system","author":"Rivi V.","year":"2022"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1086\/725689"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2023.107775"},{"key":"e_1_2_11_105_1","first-page":"904","article-title":"Comparison of behavioural and transcriptional responses to a heat stressor between freshly collected and an inbred strain of Lymnaea","volume":"101","author":"Rivi V.","year":"2023","journal-title":"Canadian Journal of Zoology"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-021-01491-5"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12081100"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2022.07.007"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1159\/000527489"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.11.020"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12716"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.244844"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111408958"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666211115124639"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.11"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34327-0"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604660200"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13210"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2017.0002"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.77004"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02069"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02735"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20040031"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.159038"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.190405"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218532"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.021"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSMBR.894221"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.075960"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2020.0010"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00065"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0088-20.2020"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00053-9"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.764706"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01301-x"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.01.029"},{"key":"e_1_2_11_137_1","article-title":"The endocannabinoid system: Directing eating behavior and macronutrient metabolism","volume":"5","author":"Watkins B. A.","year":"2014","journal-title":"Frontiers in Psychology"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.595166"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511979"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.1.11"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ecolsys-011720-124613"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.363"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.070201"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.16147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T09:35:10Z","timestamp":1737452110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.16147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,22]]},"references-count":142,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jnc.16147"],"URL":"https:\/\/doi.org\/10.1111\/jnc.16147","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNC.16147\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16147\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16147\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16147\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNC.16147\/v1\/review2","asserted-by":"object"}]},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,22]]},"assertion":[{"value":"2024-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}