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Multiple studies have linked glutamatergic dysfunction with the pathophysiology of depression, but the exact alterations in the glutamatergic system that contribute to depressive\u2010like behaviors are not fully understood. Recent evidence suggests that a decreased level in neuronal glutamate transporter (EAAT3), known to control glutamate levels and limit the activation of glutamate receptors at synaptic sites, may contribute to the manifestation of a depressive phenotype. Here, we tested the possibility that increased EAAT3 expression at excitatory synapses could reduce the susceptibility of mice to develop depressive\u2010like behaviors when challenged to a 5\u2010week unpredictable chronic mild stress (UCMS) protocol. Mice overexpressing EAAT3 in the forebrain (EAAT3\n                    <jats:sup>glo<\/jats:sup>\n                    \/CMKII) and control littermates (EAAT3\n                    <jats:sup>glo<\/jats:sup>\n                    ) were assessed for depressive\u2010like behaviors and long\u2010term memory performance after being subjected to UCMS conditions. We found that, after UCMS, EAAT3\n                    <jats:sup>glo<\/jats:sup>\n                    \/CMKII mice did not exhibit depressive\u2010like behaviors or memory alterations observed in control mice. Moreover, we found that EAAT3\n                    <jats:sup>glo<\/jats:sup>\n                    \/CMKII mice did not show alterations in phasic dopamine release in the nucleus accumbens neither in long\u2010term synaptic plasticity in the CA1 region of the hippocampus after UCMS, as observed in control littermates. Altogether these results suggest that forebrain EAAT3 overexpression may be related to a resilient phenotype, both at behavioral and functional level, to the deleterious effect of chronic stress, highlighting the importance of neuronal EAAT3 in the pathophysiology of depressive\u2010like behaviors.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc16216-fig-0009-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  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